Is ALGN or AXSM more profitable?

ALGN runs the higher net margin — ALGN at 9.99% versus AXSM at -24.68%.

How have ALGN and AXSM total returns compared?

Over the past 10 years, ALGN delivered 4.63% and AXSM delivered 35.76% annualized total return. Past performance doesn't predict future results.

Align Technology, Inc. (ALGN) vs Axsome Therapeutics, Inc. (AXSM)

A side-by-side comparison of Align Technology, Inc. and Axsome Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALGN

Align Technology, Inc.

$10.13B

$141.45HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

AXSM

Axsome Therapeutics, Inc.

$8.97B

$174.34HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ALGN vs AXSM

growth of $100 · dividends reinvested · last 10y

ALGN +52.2% (+4.3%/yr)AXSM +2054.3% (+35.9%/yr)AXSM compounded faster over this window

Log scale — wide-divergence pair

ALGN AXSM

ALGN vs AXSM: by the numbers

•ALGN is the larger company ($10.13B vs $8.97B market cap).
•ALGN is profitable (9.99% net margin) while AXSM runs a net loss (-24.68%).

Metrics side by side

Valuation

Metric	ALGN	AXSM
P/E ratio	24.56	N/A
Forward P/E	12.55	N/A
P/S ratio	2.45	11.55
P/B ratio	2.39	107.70
EV / EBITDA	11.35	N/A

Profitability

Metric	ALGN	AXSM
Gross margin	66.48%	93.24%
Operating margin	13.33%	-24.28%
Net margin	9.99%	-24.68%
ROE	9.77%	-230.05%
ROIC	8.90%	-50.82%

Growth (annualized)

Metric	ALGN	AXSM
Revenue CAGR (5Y)	3.57%	N/A
EPS CAGR (5Y)	-24.16%	N/A
Total return CAGR (5Y)	-26.34%	41.40%

Some values include inputs from SEC filing.

Frequently asked

Is ALGN or AXSM more profitable?: ALGN runs the higher net margin — ALGN at 9.99% versus AXSM at -24.68%.
How have ALGN and AXSM total returns compared?: Over the past 10 years, ALGN delivered 4.63% and AXSM delivered 35.76% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALGN analysis Full AXSM analysis Interactive comparison tool

Dig into the metrics

Align Technology P/E ratio Align Technology ROE Axsome Therapeutics ROE Align Technology operating margin Axsome Therapeutics operating margin Align Technology revenue growth Axsome Therapeutics revenue growth Align Technology free cash flow Axsome Therapeutics free cash flow

Align Technology & Axsome Therapeutics appear in these rankings

Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.