Agios Pharmaceuticals, Inc. (AGIO) vs Palvella Therapeutics, Inc. (PVLA)

A side-by-side comparison of Agios Pharmaceuticals, Inc. and Palvella Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Agios Pharmaceuticals, Inc. logo
AGIO
Agios Pharmaceuticals, Inc.
$1.90B
$31.81HealthcareDelayed quote: Oct 6, 2026, 12:30 PM EDT
Palvella Therapeutics, Inc. logo
PVLA
Palvella Therapeutics, Inc.
$1.86B
$129.56HealthcareDelayed quote: Oct 6, 2026, 12:25 PM EDT

Total return — AGIO vs PVLA

growth of $100 · dividends reinvested · last 2y
AGIO -35.8% (-19.8%/yr)PVLA +677.4% (+178.8%/yr)PVLA compounded faster over this window
Log scale — wide-divergence pair
101001kStart $10020252026$64$777
AGIO PVLA

AGIO vs PVLA: by the numbers

  • •AGIO is the larger company ($1.90B vs $1.86B market cap).
  • •Both run net losses; PVLA's is the smaller (0.00% vs -418.24% net margin).

Metrics side by side

Valuation

MetricAGIOPVLA
P/S ratio19.31N/A
P/B ratio1.858.57

Profitability

MetricAGIOPVLA
Gross margin78.67%0.00%
Operating margin-873.87%0.00%
Net margin-418.24%0.00%
ROE-40.09%-28.45%
ROIC-44.21%-23.90%

Growth (annualized)

MetricAGIOPVLA
Revenue CAGR (5Y)4.54%N/A
Total return CAGR (5Y)-6.59%N/A

Go deeper

Full AGIO analysisFull PVLA analysisInteractive comparison tool

Dig into the metrics

Agios Pharmaceuticals ROEPalvella Therapeutics ROEAgios Pharmaceuticals operating marginPalvella Therapeutics operating marginAgios Pharmaceuticals revenue growthPalvella Therapeutics revenue growthAgios Pharmaceuticals free cash flowPalvella Therapeutics free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.