Which has grown faster, AGEN or CCCC?

Over the past five years, AGEN grew revenue faster — AGEN at a 14.13% CAGR versus CCCC at 0.65%.

Is AGEN or CCCC more profitable?

AGEN runs the higher net margin — AGEN at 69.34% versus CCCC at -289.44%.

How have AGEN and CCCC total returns compared?

Over the past 5 years, AGEN delivered -40.10% and CCCC delivered -41.77% annualized total return. Past performance doesn't predict future results.

Agenus Inc. (AGEN) vs C4 Therapeutics, Inc. (CCCC)

A side-by-side comparison of Agenus Inc. and C4 Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGEN

Agenus Inc.

$364M

$8.73HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

CCCC

C4 Therapeutics, Inc.

$331M

$2.99HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

Total return — AGEN vs CCCC

growth of $100 · dividends reinvested · last 6y

AGEN -89.2% (-31.0%/yr)CCCC -88.3% (-30.0%/yr)CCCC compounded faster over this window

AGEN CCCC

AGEN vs CCCC: by the numbers

•AGEN is the larger company ($364M vs $331M market cap).
•AGEN is profitable (69.34% net margin) while CCCC runs a net loss (-289.44%).
•AGEN grew revenue faster over the past five years (14.13% vs 0.65% CAGR).

Metrics side by side

Valuation

Metric	AGEN	CCCC
P/E ratio	3.30	N/A
Forward P/E	32.64	N/A
P/S ratio	2.74	9.44
P/B ratio	N/A	1.34
EV / EBITDA	9.42	N/A

Profitability

Metric	AGEN	CCCC
Gross margin	29.63%	77.81%
Operating margin	-18.00%	-290.68%
Net margin	69.34%	-289.44%
ROE	N/A	-41.02%
ROIC	N/A	-35.92%

Growth (annualized)

Metric	AGEN	CCCC
Revenue CAGR (5Y)	14.13%	0.65%
Total return CAGR (5Y)	-40.10%	-41.77%

Frequently asked

Which has grown faster, AGEN or CCCC?: Over the past five years, AGEN grew revenue faster — AGEN at a 14.13% CAGR versus CCCC at 0.65%.
Is AGEN or CCCC more profitable?: AGEN runs the higher net margin — AGEN at 69.34% versus CCCC at -289.44%.
How have AGEN and CCCC total returns compared?: Over the past 5 years, AGEN delivered -40.10% and CCCC delivered -41.77% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AGEN analysis Full CCCC analysis Interactive comparison tool

Dig into the metrics

Agenus P/E ratio Agenus ROE C4 Therapeutics ROE Agenus operating margin C4 Therapeutics operating margin Agenus revenue growth C4 Therapeutics revenue growth Agenus free cash flow C4 Therapeutics free cash flow

Agenus & C4 Therapeutics appear in these rankings

Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.