Xeris Biopharma Holdings, Inc. (XERS) vs Xencor, Inc. (XNCR)
A side-by-side comparison of Xeris Biopharma Holdings, Inc. and Xencor, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
XERS
Xeris Biopharma Holdings, Inc.
$10.03HealthcareDelayed quote: Oct 6, 2026, 3:40 PM EDT
XNCR
Xencor, Inc.
$23.99HealthcareDelayed quote: Oct 6, 2026, 3:40 PM EDT
Total return — XERS vs XNCR
growth of $100 · dividends reinvested · last 8yXERS -49.9% (-8.3%/yr)XNCR -36.3% (-5.5%/yr)XNCR compounded faster over this window
XERS XNCR
XERS vs XNCR: by the numbers
- •XNCR is the larger company ($1.78B vs $1.73B market cap).
- •Both run net losses; XERS's is the smaller (-5.12% vs -155.59% net margin).
- •XERS grew revenue faster over the past five years (58.33% vs 0.47% CAGR).
Metrics side by side
Valuation
| Metric | XERS | XNCR |
|---|---|---|
| P/S ratio | 5.16 | 16.95 |
| P/B ratio | N/A | 3.54 |
| EV / EBITDA | 38.69 | N/A |
| FCF yield | 3.20% | N/A |
Profitability
| Metric | XERS | XNCR |
|---|---|---|
| Gross margin | 83.34% | 91.63% |
| Operating margin | 10.91% | -141.35% |
| Net margin | -5.12% | -155.59% |
| ROE | N/A | -32.46% |
| ROIC | 12.79% | -33.60% |
Growth (annualized)
| Metric | XERS | XNCR |
|---|---|---|
| Revenue CAGR (5Y) | 58.33% | 0.47% |
| Total return CAGR (5Y) | 33.72% | -6.46% |
Frequently asked
- Which has grown faster, XERS or XNCR?
- Over the past five years, XERS grew revenue faster — XERS at a 58.33% CAGR versus XNCR at 0.47%.
- How have XERS and XNCR total returns compared?
- Over the past 5 years, XERS delivered 33.72% and XNCR delivered -6.46% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Xeris Biopharma ROEXencor ROEXeris Biopharma operating marginXencor operating marginXeris Biopharma revenue growthXencor revenue growthXeris Biopharma free cash flowXencor free cash flow
Xeris Biopharma & Xencor appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.