Spero Therapeutics, Inc. (SPRO) vs Tiziana Life Sciences Ltd (TLSA)
A side-by-side comparison of Spero Therapeutics, Inc. and Tiziana Life Sciences Ltd across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
SPRO
Spero Therapeutics, Inc.
$1.19HealthcareDelayed quote: Oct 6, 2026, 2:10 PM EDT
TLSA
Tiziana Life Sciences Ltd
$1.08HealthcareDelayed quote: Oct 6, 2026, 2:10 PM EDT
Total return — SPRO vs TLSA
growth of $100 · dividends reinvested · last 8ySPRO -85.1% (-21.2%/yr)TLSA -74.3% (-15.6%/yr)TLSA compounded faster over this window
SPRO TLSA
SPRO vs TLSA: by the numbers
- •TLSA is the larger company ($69M vs $69M market cap).
- •SPRO is profitable (17.18% net margin) while TLSA runs a net loss (0.00%).
Metrics side by side
Valuation
| Metric | SPRO | TLSA |
|---|---|---|
| P/E ratio | 10.77 | N/A |
| P/S ratio | 1.60 | N/A |
| P/B ratio | 1.55 | 1321.54 |
| EV / EBITDA | 3.30 | N/A |
| FCF yield | 28.54% | N/A |
Profitability
| Metric | SPRO | TLSA |
|---|---|---|
| Gross margin | 100.00% | 0.00% |
| Operating margin | -0.04% | 0.00% |
| Net margin | 17.18% | 0.00% |
| ROE | 16.70% | -35444.23% |
| ROIC | 13.12% | N/A |
Growth (annualized)
| Metric | SPRO | TLSA |
|---|---|---|
| Revenue CAGR (5Y) | 22.93% | N/A |
| Total return CAGR (5Y) | -42.70% | -5.37% |
Frequently asked
- Is SPRO or TLSA more profitable?
- SPRO runs the higher net margin — SPRO at 17.18% versus TLSA at 0.00%.
- How have SPRO and TLSA total returns compared?
- Over the past 5 years, SPRO delivered -42.70% and TLSA delivered -5.37% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Spero Therapeutics P/E ratioSpero Therapeutics ROETiziana Life Sciences ROESpero Therapeutics operating marginTiziana Life Sciences operating marginSpero Therapeutics revenue growthTiziana Life Sciences revenue growthSpero Therapeutics free cash flowTiziana Life Sciences free cash flow
Spero Therapeutics & Tiziana Life Sciences appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.