Which has grown faster, SOPH or ZVRA?

Over the past five years, ZVRA grew revenue faster — SOPH at a 20.33% CAGR versus ZVRA at 36.81%.

Is SOPH or ZVRA more profitable?

ZVRA runs the higher net margin — SOPH at -93.86% versus ZVRA at 42.82%.

How have SOPH and ZVRA total returns compared?

Over the past 5 years, SOPH delivered -13.62% and ZVRA delivered 3.75% annualized total return. Past performance doesn't predict future results.

SOPHiA GENETICS S.A. (SOPH) vs Zevra Therapeutics, Inc. (ZVRA)

A side-by-side comparison of SOPHiA GENETICS S.A. and Zevra Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

SOPH

SOPHiA GENETICS S.A.

$628M

$7.48HealthcareDelayed quote: Oct 6, 2026, 3:50 PM EDT

ZVRA

Zevra Therapeutics, Inc.

$632M

$10.69HealthcareDelayed quote: Oct 6, 2026, 3:50 PM EDT

Total return — SOPH vs ZVRA

growth of $100 · dividends reinvested · last 5y

SOPH -51.1% (-13.3%/yr)ZVRA -2.6% (-0.5%/yr)ZVRA compounded faster over this window

SOPH ZVRA

SOPH vs ZVRA: by the numbers

•ZVRA is the larger company ($632M vs $628M market cap).
•ZVRA is profitable (42.82% net margin) while SOPH runs a net loss (-93.86%).
•ZVRA grew revenue faster over the past five years (36.81% vs 20.33% CAGR).

Metrics side by side

Valuation

Metric	SOPH	ZVRA
P/E ratio	N/A	11.49
Forward P/E	N/A	9.64
P/S ratio	7.28	4.64
P/B ratio	7.55	2.90
EV / EBITDA	N/A	12.05
FCF yield	N/A	5.15%

Profitability

Metric	SOPH	ZVRA
Gross margin	66.63%	84.52%
Operating margin	-85.01%	-3.98%
Net margin	-93.86%	42.82%
ROE	-97.31%	26.77%
ROIC	-49.73%	12.93%

Growth (annualized)

Metric	SOPH	ZVRA
Revenue CAGR (5Y)	20.33%	36.81%
Total return CAGR (5Y)	-13.62%	3.75%

Frequently asked

Which has grown faster, SOPH or ZVRA?: Over the past five years, ZVRA grew revenue faster — SOPH at a 20.33% CAGR versus ZVRA at 36.81%.
Is SOPH or ZVRA more profitable?: ZVRA runs the higher net margin — SOPH at -93.86% versus ZVRA at 42.82%.
How have SOPH and ZVRA total returns compared?: Over the past 5 years, SOPH delivered -13.62% and ZVRA delivered 3.75% annualized total return. Past performance doesn't predict future results.

Go deeper

Full SOPH analysis Full ZVRA analysis Interactive comparison tool

Dig into the metrics

Zevra Therapeutics P/E ratio SOPHiA GENETICS ROE Zevra Therapeutics ROE SOPHiA GENETICS operating margin Zevra Therapeutics operating margin SOPHiA GENETICS revenue growth Zevra Therapeutics revenue growth SOPHiA GENETICS free cash flow Zevra Therapeutics free cash flow

SOPHiA GENETICS & Zevra Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.