Septerna Inc (SEPN) vs DENTSPLY SIRONA Inc. (XRAY)

A side-by-side comparison of Septerna Inc and DENTSPLY SIRONA Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Septerna Inc logo
SEPN
Septerna Inc
$1.63B
$36.15HealthcareDelayed quote: Oct 6, 2026, 2:44 PM EDT
DENTSPLY SIRONA Inc. logo
XRAY
DENTSPLY SIRONA Inc.
$1.71B
$8.52HealthcareDelayed quote: Oct 6, 2026, 2:45 PM EDT

Total return — SEPN vs XRAY

growth of $100 · dividends reinvested · last 2y
SEPN +77.0% (+33.0%/yr)XRAY -63.3% (-39.4%/yr)SEPN compounded faster over this window
50100150200Start $10020252026$177$37
SEPN XRAY

SEPN vs XRAY: by the numbers

  • •XRAY is the larger company ($1.71B vs $1.63B market cap).
  • •Both run net losses; XRAY's is the smaller (-14.99% vs -24.51% net margin).
  • •XRAY pays a dividend (3.74% yield), while SEPN has no payments in the available dividend history.

Metrics side by side

Valuation

MetricSEPNXRAY
Forward P/EN/A5.59
P/S ratio16.480.47
P/B ratio4.211.26
EV / EBITDAN/A4.43
FCF yield6.45%8.37%

Profitability

MetricSEPNXRAY
Gross margin99.57%49.52%
Operating margin-175.83%11.69%
Net margin-24.51%-14.99%
ROE-6.27%-40.41%
ROIC-8.93%10.03%

Dividends

MetricSEPNXRAY
Dividend yieldN/A3.74%

Growth (annualized)

MetricSEPNXRAY
Revenue CAGR (5Y)N/A1.96%
FCF CAGR (5Y)N/A-25.74%
Total return CAGR (5Y)N/A-30.27%

Frequently asked

Does SEPN or XRAY pay a bigger dividend?
XRAY pays a dividend (3.74% yield), while SEPN has no payments in the available dividend history.

Go deeper

Full SEPN analysisFull XRAY analysisInteractive comparison tool

Dig into the metrics

DENTSPLY SIRONA dividend yieldSepterna ROEDENTSPLY SIRONA ROESepterna operating marginDENTSPLY SIRONA operating marginSepterna revenue growthDENTSPLY SIRONA revenue growthSepterna free cash flowDENTSPLY SIRONA free cash flow

Septerna & DENTSPLY SIRONA appear in these rankings

Highest Dividend Yield StocksHighest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.