Septerna Inc (SEPN) vs Stoke Therapeutics, Inc. (STOK)
A side-by-side comparison of Septerna Inc and Stoke Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
SEPN
Septerna Inc
$36.15HealthcareDelayed quote: Oct 6, 2026, 2:44 PM EDT
STOK
Stoke Therapeutics, Inc.
$24.30HealthcareDelayed quote: Oct 6, 2026, 2:45 PM EDT
Total return — SEPN vs STOK
growth of $100 · dividends reinvested · last 2ySEPN +77.0% (+33.0%/yr)STOK +112.6% (+45.8%/yr)STOK compounded faster over this window
SEPN STOK
SEPN vs STOK: by the numbers
- •SEPN is the larger company ($1.63B vs $1.57B market cap).
- •Both run net losses; SEPN's is the smaller (-24.51% vs -753.60% net margin).
Metrics side by side
Valuation
| Metric | SEPN | STOK |
|---|---|---|
| P/S ratio | 16.48 | 56.82 |
| P/B ratio | 4.21 | 4.54 |
| FCF yield | 6.45% | N/A |
Profitability
| Metric | SEPN | STOK |
|---|---|---|
| Gross margin | 99.57% | 100.00% |
| Operating margin | -175.83% | -11.16% |
| Net margin | -24.51% | -753.60% |
| ROE | -6.27% | -60.17% |
| ROIC | -8.93% | -63.12% |
Growth (annualized)
| Metric | SEPN | STOK |
|---|---|---|
| Total return CAGR (5Y) | N/A | -0.24% |
Go deeper
Dig into the metrics
Septerna ROEStoke Therapeutics ROESepterna operating marginStoke Therapeutics operating marginSepterna revenue growthStoke Therapeutics revenue growthSepterna free cash flowStoke Therapeutics free cash flow
Septerna & Stoke Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.