uniQure N.V. (QURE) vs Septerna Inc (SEPN)
A side-by-side comparison of uniQure N.V. and Septerna Inc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
QURE
uniQure N.V.
$23.06HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
SEPN
Septerna Inc
$35.67HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — QURE vs SEPN
growth of $100 · dividends reinvested · last 2yQURE +242.9% (+85.2%/yr)SEPN +77.0% (+33.0%/yr)QURE compounded faster over this window
QURE SEPN
QURE vs SEPN: by the numbers
- •SEPN is the larger company ($1.61B vs $1.60B market cap).
- •Both run net losses; SEPN's is the smaller (-24.51% vs -1350.73% net margin).
Metrics side by side
Valuation
| Metric | QURE | SEPN |
|---|---|---|
| P/S ratio | 85.67 | 16.26 |
| P/B ratio | 4.94 | 4.16 |
| FCF yield | N/A | 6.54% |
Profitability
| Metric | QURE | SEPN |
|---|---|---|
| Gross margin | 89.53% | 99.57% |
| Operating margin | -1166.77% | -175.83% |
| Net margin | -1350.73% | -24.51% |
| ROE | -77.83% | -6.27% |
| ROIC | -22.55% | -8.93% |
Growth (annualized)
| Metric | QURE | SEPN |
|---|---|---|
| Revenue CAGR (5Y) | -48.20% | N/A |
| Total return CAGR (5Y) | -6.16% | N/A |
Go deeper
Dig into the metrics
uniQure ROESepterna ROEuniQure operating marginSepterna operating marginuniQure revenue growthSepterna revenue growthuniQure free cash flowSepterna free cash flow
uniQure & Septerna appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.