Personalis, Inc. (PSNL) vs Septerna Inc (SEPN)
A side-by-side comparison of Personalis, Inc. and Septerna Inc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PSNL
Personalis, Inc.
$16.01HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
SEPN
Septerna Inc
$36.61HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
Total return — PSNL vs SEPN
growth of $100 · dividends reinvested · last 2yPSNL +248.9% (+86.8%/yr)SEPN +77.0% (+33.0%/yr)PSNL compounded faster over this window
PSNL SEPN
PSNL vs SEPN: by the numbers
- •PSNL is the larger company ($1.71B vs $1.65B market cap).
- •Both run net losses; SEPN's is the smaller (-24.51% vs -153.84% net margin).
Metrics side by side
Valuation
| Metric | PSNL | SEPN |
|---|---|---|
| P/S ratio | 24.52 | 16.69 |
| P/B ratio | 7.27 | 4.27 |
| FCF yield | N/A | 6.37% |
Profitability
| Metric | PSNL | SEPN |
|---|---|---|
| Gross margin | 22.65% | 99.57% |
| Operating margin | -126.43% | -175.83% |
| Net margin | -153.84% | -24.51% |
| ROE | -45.58% | -6.27% |
| ROIC | -42.87% | -8.93% |
Growth (annualized)
| Metric | PSNL | SEPN |
|---|---|---|
| Revenue CAGR (5Y) | -3.33% | N/A |
| Total return CAGR (5Y) | -1.75% | N/A |
Go deeper
Dig into the metrics
Personalis ROESepterna ROEPersonalis operating marginSepterna operating marginPersonalis revenue growthSepterna revenue growthPersonalis free cash flowSepterna free cash flow
Personalis & Septerna appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.