Prothena Corporation plc (PRTA) vs Senseonics Holdings, Inc. (SENS)
A side-by-side comparison of Prothena Corporation plc and Senseonics Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PRTA
Prothena Corporation plc
$7.90HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
SENS
Senseonics Holdings, Inc.
$10.03HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
Total return — PRTA vs SENS
growth of $100 · dividends reinvested · last 10yPRTA -86.6% (-18.2%/yr)SENS -86.3% (-18.0%/yr)SENS compounded faster over this window
PRTA SENS
PRTA vs SENS: by the numbers
- •SENS is the larger company ($419M vs $414M market cap).
- •Both run net losses; PRTA's is the smaller (-80.67% vs -225.34% net margin).
- •PRTA grew revenue faster over the past five years (62.57% vs 35.10% CAGR).
Metrics side by side
Valuation
| Metric | PRTA | SENS |
|---|---|---|
| Forward P/E | 71.82 | N/A |
| P/S ratio | 7.58 | 8.64 |
| P/B ratio | 1.44 | 4.64 |
Profitability
| Metric | PRTA | SENS |
|---|---|---|
| Gross margin | 61.77% | 44.71% |
| Operating margin | -1905.82% | -193.83% |
| Net margin | -80.67% | -225.34% |
| ROE | -15.33% | -121.12% |
| ROIC | -21.36% | -71.22% |
Growth (annualized)
| Metric | PRTA | SENS |
|---|---|---|
| Revenue CAGR (5Y) | 62.57% | 35.10% |
| Total return CAGR (5Y) | -35.08% | -30.89% |
Frequently asked
- Which has grown faster, PRTA or SENS?
- Over the past five years, PRTA grew revenue faster — PRTA at a 62.57% CAGR versus SENS at 35.10%.
- How have PRTA and SENS total returns compared?
- Over the past 10 years, PRTA delivered -18.37% and SENS delivered -18.02% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Prothena ROESenseonics ROEProthena operating marginSenseonics operating marginProthena revenue growthSenseonics revenue growthProthena free cash flowSenseonics free cash flow
Prothena & Senseonics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.