How have PRTA and RZLT total returns compared?

Over the past 10 years, PRTA delivered -18.37% and RZLT delivered -25.30% annualized total return. Past performance doesn't predict future results.

Prothena Corporation plc (PRTA) vs Rezolute, Inc. (RZLT)

A side-by-side comparison of Prothena Corporation plc and Rezolute, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

PRTA

Prothena Corporation plc

$415M

$7.93HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT

RZLT

Rezolute, Inc.

$418M

$4.34HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT

Total return — PRTA vs RZLT

growth of $100 · dividends reinvested · last 10y

PRTA -86.6% (-18.2%/yr)RZLT -94.6% (-25.3%/yr)PRTA compounded faster over this window

PRTA RZLT

PRTA vs RZLT: by the numbers

•RZLT is the larger company ($418M vs $415M market cap).
•Both run net losses; RZLT's is the smaller (0.00% vs -80.67% net margin).

Metrics side by side

Valuation

Metric	PRTA	RZLT
Forward P/E	72.09	N/A
P/S ratio	7.61	N/A
P/B ratio	1.45	4.15

Profitability

Metric	PRTA	RZLT
Gross margin	61.77%	0.00%
Operating margin	-1905.82%	0.00%
Net margin	-80.67%	0.00%
ROE	-15.33%	-77.06%
ROIC	-21.36%	-81.80%

Growth (annualized)

Metric	PRTA	RZLT
Revenue CAGR (5Y)	62.57%	N/A
Total return CAGR (5Y)	-35.08%	-9.57%

Frequently asked

How have PRTA and RZLT total returns compared?: Over the past 10 years, PRTA delivered -18.37% and RZLT delivered -25.30% annualized total return. Past performance doesn't predict future results.

Go deeper

Full PRTA analysis Full RZLT analysis Interactive comparison tool

Dig into the metrics

Prothena ROE Rezolute ROE Prothena operating margin Rezolute operating margin Prothena revenue growth Rezolute revenue growth Prothena free cash flow Rezolute free cash flow

Prothena & Rezolute appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.