Prelude Therapeutics Incorporated (PRLD) vs Sionna Therapeutics, Inc. (SION)
A side-by-side comparison of Prelude Therapeutics Incorporated and Sionna Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PRLD
Prelude Therapeutics Incorporated
$3.72HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT
SION
Sionna Therapeutics, Inc.
$4.57HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT
Total return — PRLD vs SION
growth of $100 · dividends reinvested · last 2yPRLD +239.6% (+84.3%/yr)SION -80.6% (-56.0%/yr)PRLD compounded faster over this window
Log scale — wide-divergence pair
PRLD SION
PRLD vs SION: by the numbers
- •PRLD is the larger company ($212M vs $206M market cap).
- •Both run net losses; SION's is the smaller (0.00% vs -269.75% net margin).
Metrics side by side
Valuation
| Metric | PRLD | SION |
|---|---|---|
| P/S ratio | 9.44 | N/A |
| P/B ratio | 1.58 | 0.78 |
Profitability
| Metric | PRLD | SION |
|---|---|---|
| Gross margin | 85.91% | 0.00% |
| Operating margin | -861.33% | 0.00% |
| Net margin | -269.75% | 0.00% |
| ROE | -45.23% | -36.64% |
| ROIC | -43.74% | -40.18% |
Growth (annualized)
| Metric | PRLD | SION |
|---|---|---|
| Total return CAGR (5Y) | -33.98% | N/A |
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.