Pulse Biosciences, Inc. (PLSE) vs Xenon Pharmaceuticals Inc. (XENE)
A side-by-side comparison of Pulse Biosciences, Inc. and Xenon Pharmaceuticals Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PLSE
Pulse Biosciences, Inc.
$49.12HealthcareDelayed quote: Oct 6, 2026, 1:40 PM EDT
XENE
Xenon Pharmaceuticals Inc.
$35.93HealthcareDelayed quote: Oct 6, 2026, 1:40 PM EDT
Total return — PLSE vs XENE
growth of $100 · dividends reinvested · last 10yPLSE +700.3% (+23.1%/yr)XENE +355.4% (+16.4%/yr)PLSE compounded faster over this window
PLSE XENE
PLSE vs XENE: by the numbers
- •XENE is the larger company ($3.47B vs $3.40B market cap).
- •Both run net losses; XENE's is the smaller (-4612.13% vs -6755.78% net margin).
Metrics side by side
Valuation
| Metric | PLSE | XENE |
|---|---|---|
| P/S ratio | 2868.84 | N/A |
| P/B ratio | 34.17 | 2.80 |
Profitability
| Metric | PLSE | XENE |
|---|---|---|
| Gross margin | -360.00% | 66.09% |
| Operating margin | -21982.57% | -4974.27% |
| Net margin | -6755.78% | -4612.13% |
| ROE | -80.46% | -32.94% |
| ROIC | -79.40% | -35.27% |
Growth (annualized)
| Metric | PLSE | XENE |
|---|---|---|
| Total return CAGR (5Y) | 19.76% | 4.61% |
Frequently asked
- How have PLSE and XENE total returns compared?
- Over the past 10 years, PLSE delivered 23.22% and XENE delivered 17.07% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Pulse Biosciences ROEXenon Pharmaceuticals ROEPulse Biosciences operating marginXenon Pharmaceuticals operating marginPulse Biosciences revenue growthXenon Pharmaceuticals revenue growthPulse Biosciences free cash flowXenon Pharmaceuticals free cash flow
Pulse Biosciences & Xenon Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.