Pacific Biosciences of California, Inc. (PACB) vs SI-BONE, Inc. (SIBN)
A side-by-side comparison of Pacific Biosciences of California, Inc. and SI-BONE, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PACB
Pacific Biosciences of California, Inc.
$2.70HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
SIBN
SI-BONE, Inc.
$19.55HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — PACB vs SIBN
growth of $100 · dividends reinvested · last 8yPACB -31.3% (-4.6%/yr)SIBN -1.2% (-0.2%/yr)SIBN compounded faster over this window
PACB SIBN
PACB vs SIBN: by the numbers
- •SIBN is the larger company ($867M vs $839M market cap).
- •Both run net losses; SIBN's is the smaller (-6.85% vs -82.49% net margin).
- •SIBN grew revenue faster over the past five years (20.20% vs 8.52% CAGR).
Metrics side by side
Valuation
| Metric | PACB | SIBN |
|---|---|---|
| P/S ratio | 5.27 | 4.06 |
| P/B ratio | N/A | 4.75 |
Profitability
| Metric | PACB | SIBN |
|---|---|---|
| Gross margin | 35.97% | 79.53% |
| Operating margin | -348.46% | -8.31% |
| Net margin | -82.49% | -6.85% |
| ROE | N/A | -8.03% |
| ROIC | -23.80% | -7.88% |
Growth (annualized)
| Metric | PACB | SIBN |
|---|---|---|
| Revenue CAGR (5Y) | 8.52% | 20.20% |
| Total return CAGR (5Y) | -35.20% | -1.46% |
Frequently asked
- Which has grown faster, PACB or SIBN?
- Over the past five years, SIBN grew revenue faster — PACB at a 8.52% CAGR versus SIBN at 20.20%.
- How have PACB and SIBN total returns compared?
- Over the past 5 years, PACB delivered -35.20% and SIBN delivered -1.46% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Pacific Biosciences of California ROESI-BONE ROEPacific Biosciences of California operating marginSI-BONE operating marginPacific Biosciences of California revenue growthSI-BONE revenue growthPacific Biosciences of California free cash flowSI-BONE free cash flow
Pacific Biosciences of California & SI-BONE appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.