Is OMER or TSHA more profitable?

OMER runs the higher net margin — OMER at 324.88% versus TSHA at -2728.04%.

How have OMER and TSHA total returns compared?

Over the past 5 years, OMER delivered 21.70% and TSHA delivered -25.17% annualized total return. Past performance doesn't predict future results.

Omeros Corporation (OMER) vs Taysha Gene Therapies, Inc. (TSHA)

A side-by-side comparison of Omeros Corporation and Taysha Gene Therapies, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

OMER

Omeros Corporation

$1.34B

$18.58HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT

TSHA

Taysha Gene Therapies, Inc.

$1.40B

$4.38HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT

Total return — OMER vs TSHA

growth of $100 · dividends reinvested · last 6y

OMER +53.5% (+7.4%/yr)TSHA -81.3% (-24.4%/yr)OMER compounded faster over this window

Log scale — wide-divergence pair

OMER TSHA

OMER vs TSHA: by the numbers

•TSHA is the larger company ($1.40B vs $1.34B market cap).
•OMER is profitable (324.88% net margin) while TSHA runs a net loss (-2728.04%).

Metrics side by side

Valuation

Metric	OMER	TSHA
P/E ratio	10.80	N/A
Forward P/E	20.49	N/A
P/S ratio	35.00	255.42
P/B ratio	N/A	3.62

Profitability

Metric	OMER	TSHA
Gross margin	0.00%	100.00%
Operating margin	0.00%	-1130.65%
Net margin	324.88%	-2728.04%
ROE	N/A	-38.64%
ROIC	-32.06%	-34.46%

Growth (annualized)

Metric	OMER	TSHA
Revenue CAGR (5Y)	0.90%	N/A
Total return CAGR (5Y)	21.70%	-25.17%

Frequently asked

Is OMER or TSHA more profitable?: OMER runs the higher net margin — OMER at 324.88% versus TSHA at -2728.04%.
How have OMER and TSHA total returns compared?: Over the past 5 years, OMER delivered 21.70% and TSHA delivered -25.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full OMER analysis Full TSHA analysis Interactive comparison tool

Dig into the metrics

Omeros P/E ratio Omeros ROE Taysha Gene Therapies ROE Omeros operating margin Taysha Gene Therapies operating margin Omeros revenue growth Taysha Gene Therapies revenue growth Omeros free cash flow Taysha Gene Therapies free cash flow

Omeros & Taysha Gene Therapies appear in these rankings

Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.