Ocular Therapeutix, Inc. (OCUL) vs Septerna Inc (SEPN)
A side-by-side comparison of Ocular Therapeutix, Inc. and Septerna Inc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
OCUL
Ocular Therapeutix, Inc.
$7.30HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT
SEPN
Septerna Inc
$35.78HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT
Total return — OCUL vs SEPN
growth of $100 · dividends reinvested · last 2yOCUL -33.4% (-18.4%/yr)SEPN +77.0% (+33.0%/yr)SEPN compounded faster over this window
OCUL SEPN
OCUL vs SEPN: by the numbers
- •SEPN is the larger company ($1.61B vs $1.60B market cap).
- •Both run net losses; SEPN's is the smaller (-24.51% vs -579.10% net margin).
Metrics side by side
Valuation
| Metric | OCUL | SEPN |
|---|---|---|
| P/S ratio | 30.71 | 16.31 |
| P/B ratio | 3.07 | 4.17 |
| FCF yield | N/A | 6.52% |
Profitability
| Metric | OCUL | SEPN |
|---|---|---|
| Gross margin | 87.11% | 99.57% |
| Operating margin | -521.04% | -175.83% |
| Net margin | -579.10% | -24.51% |
| ROE | -57.97% | -6.27% |
| ROIC | -50.20% | -8.93% |
Growth (annualized)
| Metric | OCUL | SEPN |
|---|---|---|
| Revenue CAGR (5Y) | 10.03% | N/A |
| Total return CAGR (5Y) | -5.73% | N/A |
Go deeper
Dig into the metrics
Ocular Therapeutix ROESepterna ROEOcular Therapeutix operating marginSepterna operating marginOcular Therapeutix revenue growthSepterna revenue growthOcular Therapeutix free cash flowSepterna free cash flow
Ocular Therapeutix & Septerna appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.