Intellia Therapeutics, Inc. (NTLA) vs Shoulder Innovations, Inc. (SI)
A side-by-side comparison of Intellia Therapeutics, Inc. and Shoulder Innovations, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 2, 2026. Differences are shown without an overall score or investment verdict.
NTLA
Intellia Therapeutics, Inc.
$12.26HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT
SI
Shoulder Innovations, Inc.
$19.01HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT
Total return — NTLA vs SI
growth of $100 · dividends reinvested · last 1yNTLA -3.0% (-3.0%/yr)SI +24.6% (+24.6%/yr)SI compounded faster over this window
NTLA SI
NTLA vs SI: by the numbers
- •NTLA is the larger company ($1.71B vs $394M market cap).
- •Both run net losses; SI's is the smaller (-58.33% vs -672.16% net margin).
Metrics side by side
Valuation
| Metric | NTLA | SI |
|---|---|---|
| P/S ratio | 28.79 | 6.56 |
| P/B ratio | 2.35 | 3.17 |
Profitability
| Metric | NTLA | SI |
|---|---|---|
| Gross margin | 76.47% | 77.34% |
| Operating margin | -651.67% | -58.53% |
| Net margin | -672.16% | -58.33% |
| ROE | -54.96% | -28.18% |
| ROIC | -54.45% | -25.26% |
Growth (annualized)
| Metric | NTLA | SI |
|---|---|---|
| Revenue CAGR (5Y) | 7.31% | N/A |
| Total return CAGR (5Y) | -38.17% | N/A |
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 2, 2026.