Neurogene Inc. (NGNE) vs Shoulder Innovations, Inc. (SI)

A side-by-side comparison of Neurogene Inc. and Shoulder Innovations, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

NGNE

Neurogene Inc.

$402M

$25.47HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

Shoulder Innovations, Inc.

$398M

$19.20HealthcareDelayed quote: Oct 6, 2026, 3:33 PM EDT

Total return — NGNE vs SI

growth of $100 · dividends reinvested · last 1y

NGNE +22.1% (+22.1%/yr)SI +30.2% (+30.2%/yr)SI compounded faster over this window

NGNE SI

NGNE vs SI: by the numbers

•NGNE is the larger company ($402M vs $398M market cap).
•Both run net losses; NGNE's is the smaller (0.00% vs -58.33% net margin).

Metrics side by side

Valuation

Metric	NGNE	SI
P/S ratio	N/A	6.63
P/B ratio	1.85	3.20

Profitability

Metric	NGNE	SI
Gross margin	0.00%	77.34%
Operating margin	0.00%	-58.53%
Net margin	0.00%	-58.33%
ROE	-51.17%	-28.18%
ROIC	-54.45%	-25.26%

Growth (annualized)

Metric	NGNE	SI
Total return CAGR (5Y)	-27.73%	N/A

Go deeper

Full NGNE analysis Full SI analysis Interactive comparison tool

Dig into the metrics

Neurogene ROE Shoulder Innovations ROE Neurogene operating margin Shoulder Innovations operating margin Neurogene revenue growth Shoulder Innovations revenue growth Neurogene free cash flow Shoulder Innovations free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.