How have NGNE and PRTA total returns compared?

Over the past 10 years, NGNE delivered -21.02% and PRTA delivered -18.37% annualized total return. Past performance doesn't predict future results.

Neurogene Inc. (NGNE) vs Prothena Corporation plc (PRTA)

A side-by-side comparison of Neurogene Inc. and Prothena Corporation plc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

NGNE

Neurogene Inc.

$407M

$25.76HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT

PRTA

Prothena Corporation plc

$412M

$7.86HealthcareDelayed quote: Oct 6, 2026, 1:49 PM EDT

Total return — NGNE vs PRTA

growth of $100 · dividends reinvested · last 10y

NGNE -90.2% (-20.8%/yr)PRTA -86.6% (-18.2%/yr)PRTA compounded faster over this window

NGNE PRTA

NGNE vs PRTA: by the numbers

•PRTA is the larger company ($412M vs $407M market cap).
•Both run net losses; NGNE's is the smaller (0.00% vs -80.67% net margin).

Metrics side by side

Valuation

Metric	NGNE	PRTA
Forward P/E	N/A	71.48
P/S ratio	N/A	7.55
P/B ratio	1.87	1.43

Profitability

Metric	NGNE	PRTA
Gross margin	0.00%	61.77%
Operating margin	0.00%	-1905.82%
Net margin	0.00%	-80.67%
ROE	-51.17%	-15.33%
ROIC	-54.45%	-21.36%

Growth (annualized)

Metric	NGNE	PRTA
Revenue CAGR (5Y)	N/A	62.57%
Total return CAGR (5Y)	-27.73%	-35.08%

Frequently asked

How have NGNE and PRTA total returns compared?: Over the past 10 years, NGNE delivered -21.02% and PRTA delivered -18.37% annualized total return. Past performance doesn't predict future results.

Go deeper

Full NGNE analysis Full PRTA analysis Interactive comparison tool

Dig into the metrics

Neurogene ROE Prothena ROE Neurogene operating margin Prothena operating margin Neurogene revenue growth Prothena revenue growth Neurogene free cash flow Prothena free cash flow

Neurogene & Prothena appear in these rankings

Fastest Revenue Growth Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.