Microsoft Corporation (MSFT) vs Pfizer Inc. (PFE)
A side-by-side comparison of Microsoft Corporation and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.
Different business models: MSFT is classified in Technology; PFE is classified in Healthcare. Margin, capital intensity, and valuation differences should be interpreted in that sector context.
MSFT
Microsoft Corporation
$393.35TechnologyDelayed quote: Jul 28, 2026, 4:00 PM EDT
PFE
Pfizer Inc.
$25.25HealthcareDelayed quote: Jul 28, 2026, 4:02 PM EDT
Total return — MSFT vs PFE
growth of $100 · dividends reinvested · last 30yMSFT +7530.9%PFE +543.3%MSFT compounded faster
Log scale — wide-divergence pair
MSFT PFE
MSFT vs PFE: by the numbers
- •MSFT is the larger company ($2.92T vs $143.91B market cap).
- •PFE trades at the lower trailing earnings multiple (18.83 vs 23.16 P/E), one valuation lens rather than an overall verdict.
- •MSFT converts more revenue to profit (39.34% vs 11.83% net margin).
- •MSFT grew revenue faster over the past five years (14.75% vs 8.22% CAGR).
- •PFE pays the higher dividend yield (6.97% vs 0.91%).
Metrics side by side
Valuation
| Metric | MSFT | PFE |
|---|---|---|
| P/E ratio | 23.16 | 18.83 |
| Forward P/E | 22.87 | 8.38 |
| P/S ratio | 9.10 | 2.23 |
| P/B ratio | 6.99 | 1.57 |
| PEG ratio | 2.34 | N/A |
| EV / EBITDA | 15.53 | 9.72 |
| FCF yield | 2.52% | 6.71% |
Profitability
| Metric | MSFT | PFE |
|---|---|---|
| Gross margin | 68.31% | 69.35% |
| Operating margin | 46.80% | 23.45% |
| Net margin | 39.34% | 11.83% |
| ROE | 30.22% | 8.31% |
| ROIC | 21.63% | 8.84% |
Dividends
| Metric | MSFT | PFE |
|---|---|---|
| Dividend yield | 0.91% | 6.97% |
| Payout ratio | 25.99% | 126.47% |
Growth (annualized)
| Metric | MSFT | PFE |
|---|---|---|
| Revenue CAGR (5Y) | 14.75% | 8.22% |
| EPS CAGR (5Y) | 18.68% | -3.78% |
| FCF CAGR (5Y) | 6.27% | -3.79% |
| Total return CAGR (5Y) | 7.19% | -5.21% |
Frequently asked
- Which has the lower trailing P/E, MSFT or PFE?
- PFE has the lower trailing P/E: MSFT trades at 23.16 and PFE at 18.83. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, MSFT or PFE?
- Over the past five years, MSFT grew revenue faster — MSFT at a 14.75% CAGR versus PFE at 8.22%.
- Does MSFT or PFE pay a bigger dividend?
- MSFT yields 0.91% and PFE yields 6.97% based on trailing dividends and the latest price.
- Is MSFT or PFE more profitable?
- MSFT runs the higher net margin — MSFT at 39.34% versus PFE at 11.83%.
- How have MSFT and PFE total returns compared?
- Over the past 10 years, MSFT delivered 22.86% and PFE delivered 1.55% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Microsoft P/E ratioPfizer P/E ratioMicrosoft dividend yieldPfizer dividend yieldMicrosoft ROEPfizer ROEMicrosoft operating marginPfizer operating marginMicrosoft revenue growthPfizer revenue growthMicrosoft free cash flowPfizer free cash flow
Microsoft & Pfizer appear in these rankings
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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.