MapLight Therapeutics, Inc. (MPLT) vs Orchestra BioMed Holdings, Inc. (OBIO)
A side-by-side comparison of MapLight Therapeutics, Inc. and Orchestra BioMed Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
MPLT
MapLight Therapeutics, Inc.
$9.35HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT
OBIO
Orchestra BioMed Holdings, Inc.
$5.84HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT
Total return — MPLT vs OBIO
growth of $100 · dividends reinvested · last 1yMPLT -49.4% (-49.4%/yr)OBIO +52.7% (+52.7%/yr)OBIO compounded faster over this window
MPLT OBIO
MPLT vs OBIO: by the numbers
- •MPLT is the larger company ($397M vs $350M market cap).
- •Both run net losses; MPLT's is the smaller (0.00% vs -184.60% net margin).
Metrics side by side
Valuation
| Metric | MPLT | OBIO |
|---|---|---|
| P/S ratio | N/A | 10.94 |
| P/B ratio | 1.14 | 18.10 |
Profitability
| Metric | MPLT | OBIO |
|---|---|---|
| Gross margin | 0.00% | 99.32% |
| Operating margin | 0.00% | -154.73% |
| Net margin | 0.00% | -184.60% |
| ROE | -65.99% | -200.64% |
| ROIC | -69.35% | -56.73% |
Growth (annualized)
| Metric | MPLT | OBIO |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 148.45% |
| Total return CAGR (5Y) | N/A | -9.35% |
Go deeper
Dig into the metrics
MapLight Therapeutics ROEOrchestra BioMed ROEMapLight Therapeutics operating marginOrchestra BioMed operating marginMapLight Therapeutics revenue growthOrchestra BioMed revenue growthMapLight Therapeutics free cash flowOrchestra BioMed free cash flow
MapLight Therapeutics & Orchestra BioMed appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.