How have MNKD and TYRA total returns compared?

Over the past 5 years, MNKD delivered -4.18% and TYRA delivered 9.23% annualized total return. Past performance doesn't predict future results.

MannKind Corporation (MNKD) vs Tyra Biosciences, Inc. (TYRA)

A side-by-side comparison of MannKind Corporation and Tyra Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

MNKD

MannKind Corporation

$1.21B

$3.79HealthcareDelayed quote: Oct 6, 2026, 2:25 PM EDT

TYRA

Tyra Biosciences, Inc.

$1.20B

$20.18HealthcareDelayed quote: Oct 6, 2026, 2:25 PM EDT

Total return — MNKD vs TYRA

growth of $100 · dividends reinvested · last 5y

MNKD -18.2% (-3.9%/yr)TYRA -19.5% (-4.2%/yr)MNKD compounded faster over this window

MNKD TYRA

MNKD vs TYRA: by the numbers

•MNKD is the larger company ($1.21B vs $1.20B market cap).
•Both run net losses; TYRA's is the smaller (0.00% vs -11.08% net margin).

Metrics side by side

Valuation

Metric	MNKD	TYRA
P/S ratio	3.07	N/A
P/B ratio	N/A	3.40
EV / EBITDA	52.09	N/A

Profitability

Metric	MNKD	TYRA
Gross margin	75.69%	0.00%
Operating margin	11.12%	0.00%
Net margin	-11.08%	0.00%
ROE	N/A	-42.01%
ROIC	1.32%	-44.73%

Growth (annualized)

Metric	MNKD	TYRA
Revenue CAGR (5Y)	39.51%	N/A
Total return CAGR (5Y)	-4.18%	9.23%

Frequently asked

How have MNKD and TYRA total returns compared?: Over the past 5 years, MNKD delivered -4.18% and TYRA delivered 9.23% annualized total return. Past performance doesn't predict future results.

Go deeper

Full MNKD analysis Full TYRA analysis Interactive comparison tool

Dig into the metrics

MannKind ROE Tyra Biosciences ROE MannKind operating margin Tyra Biosciences operating margin MannKind revenue growth Tyra Biosciences revenue growth MannKind free cash flow Tyra Biosciences free cash flow

MannKind & Tyra Biosciences appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.