Is MMSI or ORKA more profitable?

MMSI runs the higher net margin — MMSI at 9.22% versus ORKA at 0.00%.

How have MMSI and ORKA total returns compared?

Over the past 10 years, MMSI delivered 13.48% and ORKA delivered -13.93% annualized total return. Past performance doesn't predict future results.

Merit Medical Systems, Inc. (MMSI) vs Oruka Therapeutics, Inc. (ORKA)

A side-by-side comparison of Merit Medical Systems, Inc. and Oruka Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

MMSI

Merit Medical Systems, Inc.

$5.06B

$84.69HealthcareDelayed quote: Oct 6, 2026, 1:49 PM EDT

ORKA

Oruka Therapeutics, Inc.

$4.79B

$79.42HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT

Total return — MMSI vs ORKA

growth of $100 · dividends reinvested · last 10y

MMSI +248.8% (+13.3%/yr)ORKA -75.7% (-13.2%/yr)MMSI compounded faster over this window

Log scale — wide-divergence pair

MMSI ORKA

MMSI vs ORKA: by the numbers

•MMSI is the larger company ($5.06B vs $4.79B market cap).
•MMSI is profitable (9.22% net margin) while ORKA runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	MMSI	ORKA
P/E ratio	34.99	N/A
Forward P/E	19.68	N/A
P/S ratio	3.20	N/A
P/B ratio	3.01	4.31
EV / EBITDA	16.10	N/A
FCF yield	4.02%	N/A

Profitability

Metric	MMSI	ORKA
Gross margin	49.52%	0.00%
Operating margin	12.75%	0.00%
Net margin	9.22%	0.00%
ROE	8.67%	-11.92%
ROIC	5.80%	-13.88%

Growth (annualized)

Metric	MMSI	ORKA
Revenue CAGR (5Y)	8.90%	N/A
FCF CAGR (5Y)	8.96%	N/A
Total return CAGR (5Y)	3.88%	32.76%

Frequently asked

Is MMSI or ORKA more profitable?: MMSI runs the higher net margin — MMSI at 9.22% versus ORKA at 0.00%.
How have MMSI and ORKA total returns compared?: Over the past 10 years, MMSI delivered 13.48% and ORKA delivered -13.93% annualized total return. Past performance doesn't predict future results.

Go deeper

Full MMSI analysis Full ORKA analysis Interactive comparison tool

Dig into the metrics

Merit Medical Systems P/E ratio Merit Medical Systems ROE Oruka Therapeutics ROE Merit Medical Systems operating margin Oruka Therapeutics operating margin Merit Medical Systems revenue growth Oruka Therapeutics revenue growth Merit Medical Systems free cash flow Oruka Therapeutics free cash flow

Merit Medical Systems & Oruka Therapeutics appear in these rankings

Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.