23andMe Holding Co. (ME) vs TransMedics Group, Inc. (TMDX)
A side-by-side comparison of 23andMe Holding Co. and TransMedics Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 4, 2026. Differences are shown without an overall score or investment verdict.
ME
23andMe Holding Co.
$0.61HealthcareAt close: Mar 19, 2026, 4:00 PM ET
TMDX
TransMedics Group, Inc.
$81.25HealthcareDelayed quote: Aug 4, 2026, 11:40 AM EDT
Total return — ME vs TMDX
growth of $100 · dividends reinvested · last 5yME -99.7%TMDX +666.0%TMDX compounded faster
Log scale — wide-divergence pair
ME TMDX
ME vs TMDX: by the numbers
- •TMDX is the larger company ($2.81B vs $15M market cap).
- •TMDX is profitable (27.04% net margin) while ME runs a net loss (-134.54%).
- •TMDX grew revenue faster over the past five years (90.79% vs -9.07% CAGR).
Metrics side by side
Valuation
| Metric | ME | TMDX |
|---|---|---|
| P/E ratio | N/A | 18.66 |
| Forward P/E | N/A | 44.58 |
| P/S ratio | 0.10 | 4.64 |
| P/B ratio | 0.51 | 5.97 |
| PEG ratio | N/A | 0.05 |
| EV / EBITDA | N/A | 26.33 |
| FCF yield | N/A | 5.13% |
Profitability
| Metric | ME | TMDX |
|---|---|---|
| Gross margin | 53.33% | 59.09% |
| Operating margin | -126.72% | 14.85% |
| Net margin | -134.54% | 27.04% |
| ROE | -721.75% | 34.80% |
| ROIC | -553.10% | 10.94% |
Growth (annualized)
| Metric | ME | TMDX |
|---|---|---|
| Revenue CAGR (5Y) | -9.07% | 90.79% |
| Total return CAGR (5Y) | -68.93% | 23.91% |
Frequently asked
- Which has grown faster, ME or TMDX?
- Over the past five years, TMDX grew revenue faster — ME at a -9.07% CAGR versus TMDX at 90.79%.
- Is ME or TMDX more profitable?
- TMDX runs the higher net margin — ME at -134.54% versus TMDX at 27.04%.
- How have ME and TMDX total returns compared?
- Over the past 5 years, ME delivered -68.93% and TMDX delivered 23.91% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
23andMe P/E ratioTransMedics P/E ratio23andMe dividend yieldTransMedics dividend yield23andMe ROETransMedics ROE23andMe operating marginTransMedics operating margin23andMe revenue growthTransMedics revenue growth23andMe free cash flowTransMedics free cash flow
23andMe & TransMedics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 4, 2026.