23andMe Holding Co. (ME) vs TransMedics Group, Inc. (TMDX)

TMDX leads on 7 of 9 compared metrics.

A side-by-side comparison of 23andMe Holding Co. and TransMedics Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 20, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Compare

Total return — ME vs TMDX

growth of $100 · last 5y
ME -99.7%TMDX +703.1%TMDX compounded faster
Log scale — wide-divergence pair
01101001k10kStart $100202120222023202420252026$0$803
ME TMDX

ME vs TMDX: by the numbers

  • TMDX is the larger company ($2.72B vs $15M market cap).
  • TMDX is profitable (27.04% net margin) while ME runs a net loss (-134.54%).
  • TMDX grew revenue faster over the past five years (90.79% vs -9.07% CAGR).

Which is better, ME or TMDX?

Metric tally: ME 2 · TMDX 7

It depends on what you're optimizing for:

GrowthTMDX(faster 5Y revenue CAGR)
QualityTMDX(higher ROIC)

Metrics side by side

Valuation

MetricMETMDX
P/E ratio18.03
Forward P/E38.89
P/S ratio0.104.48
P/B ratio0.515.77
PEG ratio0.05
EV / EBITDA23.28
FCF yield5.31%

Profitability

MetricMETMDX
Gross margin53.33%59.09%
Operating margin-114.00%14.85%
Net margin-134.54%27.04%
ROE-721.75%34.80%
ROIC-553.10%10.94%

Growth (annualized)

MetricMETMDX
Revenue CAGR (5Y)-9.07%90.79%
Total return CAGR (5Y)-68.93%21.48%

Frequently asked

Which is better, ME or TMDX?
It depends on your goal. growth: TMDX (faster 5Y revenue CAGR); quality: TMDX (higher ROIC). Across all compared metrics, TMDX leads 7 to 2.
Which has grown faster, ME or TMDX?
Over the past five years, TMDX grew revenue faster — ME at a -9.07% CAGR versus TMDX at 90.79%.
Is ME or TMDX more profitable?
TMDX runs the higher net margin — ME at -134.54% versus TMDX at 27.04%.
Which has been the better investment, ME or TMDX?
Over the past 5-year, TMDX delivered the higher annualized total return — ME at -68.93% versus TMDX at 21.48%. Past performance doesn't predict future results.

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 20, 2026.