23andMe Holding Co. (ME) vs TransMedics Group, Inc. (TMDX)
TMDX leads on 7 of 9 compared metrics.
A side-by-side comparison of 23andMe Holding Co. and TransMedics Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 20, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
Total return — ME vs TMDX
growth of $100 · last 5yME -99.7%TMDX +703.1%TMDX compounded faster
Log scale — wide-divergence pair
ME TMDX
ME vs TMDX: by the numbers
- •TMDX is the larger company ($2.72B vs $15M market cap).
- •TMDX is profitable (27.04% net margin) while ME runs a net loss (-134.54%).
- •TMDX grew revenue faster over the past five years (90.79% vs -9.07% CAGR).
Which is better, ME or TMDX?
Metric tally: ME 2 · TMDX 7It depends on what you're optimizing for:
GrowthTMDX(faster 5Y revenue CAGR)
QualityTMDX(higher ROIC)
Metrics side by side
Valuation
| Metric | ME | TMDX |
|---|---|---|
| P/E ratio | — | 18.03 |
| Forward P/E | — | 38.89 |
| P/S ratio | 0.10● | 4.48 |
| P/B ratio | 0.51● | 5.77 |
| PEG ratio | — | 0.05 |
| EV / EBITDA | — | 23.28 |
| FCF yield | — | 5.31% |
Profitability
| Metric | ME | TMDX |
|---|---|---|
| Gross margin | 53.33% | 59.09%● |
| Operating margin | -114.00% | 14.85%● |
| Net margin | -134.54% | 27.04%● |
| ROE | -721.75% | 34.80%● |
| ROIC | -553.10% | 10.94%● |
Growth (annualized)
| Metric | ME | TMDX |
|---|---|---|
| Revenue CAGR (5Y) | -9.07% | 90.79%● |
| Total return CAGR (5Y) | -68.93% | 21.48%● |
Frequently asked
- Which is better, ME or TMDX?
- It depends on your goal. growth: TMDX (faster 5Y revenue CAGR); quality: TMDX (higher ROIC). Across all compared metrics, TMDX leads 7 to 2.
- Which has grown faster, ME or TMDX?
- Over the past five years, TMDX grew revenue faster — ME at a -9.07% CAGR versus TMDX at 90.79%.
- Is ME or TMDX more profitable?
- TMDX runs the higher net margin — ME at -134.54% versus TMDX at 27.04%.
- Which has been the better investment, ME or TMDX?
- Over the past 5-year, TMDX delivered the higher annualized total return — ME at -68.93% versus TMDX at 21.48%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
23andMe P/E ratioTransMedics P/E ratio23andMe dividend yieldTransMedics dividend yield23andMe ROETransMedics ROE23andMe operating marginTransMedics operating margin23andMe revenue growthTransMedics revenue growth23andMe free cash flowTransMedics free cash flow
23andMe & TransMedics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 20, 2026.