23andMe Holding Co. (ME) vs Shoulder Innovations, Inc. (SI)
SI leads on 5 of 7 compared metrics.
A side-by-side comparison of 23andMe Holding Co. and Shoulder Innovations, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 21, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
Total return — ME vs SI
growth of $100 · last 1yME -87.7%SI +0.0%SI compounded faster
Log scale — wide-divergence pair
ME SI
ME vs SI: by the numbers
- •SI is the larger company ($385M vs $15M market cap).
- •Both run net losses; SI's is the smaller (-81.78% vs -134.54% net margin).
Metrics side by side
Valuation
| Metric | ME | SI |
|---|---|---|
| P/S ratio | 0.10● | 7.11 |
| P/B ratio | 0.51● | 2.88 |
Profitability
| Metric | ME | SI |
|---|---|---|
| Gross margin | 53.33% | 75.48%● |
| Operating margin | -114.00% | -57.48%● |
| Net margin | -134.54% | -81.78%● |
| ROE | -721.75% | -33.14%● |
| ROIC | -553.10% | -14.80%● |
Growth (annualized)
| Metric | ME | SI |
|---|---|---|
| Revenue CAGR (5Y) | -9.07% | — |
| Total return CAGR (5Y) | -68.93% | — |
Go deeper
Dig into the metrics
23andMe P/E ratioShoulder Innovations P/E ratio23andMe dividend yieldShoulder Innovations dividend yield23andMe ROEShoulder Innovations ROE23andMe operating marginShoulder Innovations operating margin23andMe revenue growthShoulder Innovations revenue growth23andMe free cash flowShoulder Innovations free cash flow
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 21, 2026.