23andMe Holding Co. (ME) vs Shoulder Innovations, Inc. (SI)
A side-by-side comparison of 23andMe Holding Co. and Shoulder Innovations, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 5, 2026. Differences are shown without an overall score or investment verdict.
ME
23andMe Holding Co.
$0.61HealthcareAt close: Mar 19, 2026, 4:00 PM ET
SI
Shoulder Innovations, Inc.
$22.48HealthcareDelayed quote: Aug 5, 2026, 2:45 PM EDT
Total return — ME vs SI
growth of $100 · dividends reinvested · last 1yME -87.7%SI +0.0%SI compounded faster
Log scale — wide-divergence pair
ME SI
ME vs SI: by the numbers
- •SI is the larger company ($466M vs $15M market cap).
- •Both run net losses; SI's is the smaller (-81.78% vs -134.54% net margin).
Metrics side by side
Valuation
| Metric | ME | SI |
|---|---|---|
| P/S ratio | 0.10 | 8.70 |
| P/B ratio | 0.51 | 3.52 |
Profitability
| Metric | ME | SI |
|---|---|---|
| Gross margin | 53.33% | 75.48% |
| Operating margin | -126.72% | -57.48% |
| Net margin | -134.54% | -81.78% |
| ROE | -721.75% | -33.14% |
| ROIC | -553.10% | -14.80% |
Growth (annualized)
| Metric | ME | SI |
|---|---|---|
| Revenue CAGR (5Y) | -9.07% | N/A |
| Total return CAGR (5Y) | -68.93% | N/A |
Go deeper
Dig into the metrics
23andMe P/E ratioShoulder Innovations P/E ratio23andMe dividend yieldShoulder Innovations dividend yield23andMe ROEShoulder Innovations ROE23andMe operating marginShoulder Innovations operating margin23andMe revenue growthShoulder Innovations revenue growth23andMe free cash flowShoulder Innovations free cash flow
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 5, 2026.