Lyell Immunopharma, Inc. (LYEL) vs Sionna Therapeutics, Inc. (SION)
A side-by-side comparison of Lyell Immunopharma, Inc. and Sionna Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
LYEL
Lyell Immunopharma, Inc.
$8.61HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
SION
Sionna Therapeutics, Inc.
$4.75HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — LYEL vs SION
growth of $100 · dividends reinvested · last 2yLYEL -23.3% (-12.4%/yr)SION -80.6% (-56.0%/yr)LYEL compounded faster over this window
LYEL SION
LYEL vs SION: by the numbers
- •SION is the larger company ($214M vs $211M market cap).
- •Both run net losses; SION's is the smaller (0.00% vs -920285.19% net margin).
Metrics side by side
Valuation
| Metric | LYEL | SION |
|---|---|---|
| P/S ratio | 7814.17 | N/A |
| P/B ratio | 0.90 | 0.81 |
Profitability
| Metric | LYEL | SION |
|---|---|---|
| Gross margin | -31952.78% | 0.00% |
| Operating margin | -566038.89% | 0.00% |
| Net margin | -920285.19% | 0.00% |
| ROE | -106.27% | -36.64% |
| ROIC | -70.80% | -40.18% |
Growth (annualized)
| Metric | LYEL | SION |
|---|---|---|
| Revenue CAGR (5Y) | -68.32% | N/A |
| Total return CAGR (5Y) | -48.18% | N/A |
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.