Lyell Immunopharma, Inc. (LYEL) vs Profound Medical Corp. (PROF)
A side-by-side comparison of Lyell Immunopharma, Inc. and Profound Medical Corp. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
LYEL
Lyell Immunopharma, Inc.
$8.64HealthcareDelayed quote: Oct 6, 2026, 3:20 PM EDT
PROF
Profound Medical Corp.
$6.07HealthcareDelayed quote: Oct 6, 2026, 3:19 PM EDT
Total return — LYEL vs PROF
growth of $100 · dividends reinvested · last 5yLYEL -97.3% (-51.5%/yr)PROF -68.7% (-20.8%/yr)PROF compounded faster over this window
Log scale — wide-divergence pair
LYEL PROF
LYEL vs PROF: by the numbers
- •PROF is the larger company ($221M vs $212M market cap).
- •Both run net losses; PROF's is the smaller (-171.72% vs -920285.19% net margin).
- •PROF grew revenue faster over the past five years (16.55% vs -68.32% CAGR).
Metrics side by side
Valuation
| Metric | LYEL | PROF |
|---|---|---|
| P/S ratio | 7841.39 | 11.60 |
| P/B ratio | 0.91 | 4.43 |
Profitability
| Metric | LYEL | PROF |
|---|---|---|
| Gross margin | -31952.78% | 71.79% |
| Operating margin | -566038.89% | -256.27% |
| Net margin | -920285.19% | -171.72% |
| ROE | -106.27% | -65.59% |
| ROIC | -70.80% | -61.03% |
Growth (annualized)
| Metric | LYEL | PROF |
|---|---|---|
| Revenue CAGR (5Y) | -68.32% | 16.55% |
| Total return CAGR (5Y) | -48.18% | -15.23% |
Frequently asked
- Which has grown faster, LYEL or PROF?
- Over the past five years, PROF grew revenue faster — LYEL at a -68.32% CAGR versus PROF at 16.55%.
- How have LYEL and PROF total returns compared?
- Over the past 5 years, LYEL delivered -48.18% and PROF delivered -15.23% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Lyell Immunopharma ROEProfound Medical ROELyell Immunopharma operating marginProfound Medical operating marginLyell Immunopharma revenue growthProfound Medical revenue growthLyell Immunopharma free cash flowProfound Medical free cash flow
Lyell Immunopharma & Profound Medical appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.