LENZ Therapeutics, Inc. (LENZ) vs Spruce Biosciences, Inc. (SPRB)
A side-by-side comparison of LENZ Therapeutics, Inc. and Spruce Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
LENZ
LENZ Therapeutics, Inc.
$3.76HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT
SPRB
Spruce Biosciences, Inc.
$43.49HealthcareDelayed quote: Oct 6, 2026, 2:12 PM EDT
Total return — LENZ vs SPRB
growth of $100 · dividends reinvested · last 5yLENZ -91.4% (-38.7%/yr)SPRB -94.5% (-44.0%/yr)LENZ compounded faster over this window
LENZ SPRB
LENZ vs SPRB: by the numbers
- •SPRB is the larger company ($120M vs $118M market cap).
- •Both run net losses; SPRB's is the smaller (0.00% vs -586.74% net margin).
Metrics side by side
Valuation
| Metric | LENZ | SPRB |
|---|---|---|
| P/S ratio | 5.49 | N/A |
| P/B ratio | 0.54 | 1.43 |
Profitability
| Metric | LENZ | SPRB |
|---|---|---|
| Gross margin | 90.14% | 0.00% |
| Operating margin | -477.46% | 0.00% |
| Net margin | -586.74% | 0.00% |
| ROE | -57.47% | -61.33% |
| ROIC | -61.84% | -50.67% |
Growth (annualized)
| Metric | LENZ | SPRB |
|---|---|---|
| Total return CAGR (5Y) | -35.49% | -36.23% |
Frequently asked
- How have LENZ and SPRB total returns compared?
- Over the past 5 years, LENZ delivered -35.49% and SPRB delivered -36.23% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.