Which has the lower trailing P/E, KRYS or RGEN?

KRYS has the lower trailing P/E: KRYS trades at 40.95 and RGEN at 239.53. P/E is one valuation measure and does not by itself establish which business is cheaper.

Is KRYS or RGEN more profitable?

KRYS runs the higher net margin — KRYS at 54.82% versus RGEN at 5.29%.

How have KRYS and RGEN total returns compared?

Over the past 5 years, KRYS delivered 44.28% and RGEN delivered -6.86% annualized total return. Past performance doesn't predict future results.

Krystal Biotech, Inc. (KRYS) vs Repligen Corporation (RGEN)

A side-by-side comparison of Krystal Biotech, Inc. and Repligen Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

KRYS

Krystal Biotech, Inc.

$9.63B

$326.81HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

RGEN

Repligen Corporation

$9.87B

$174.86HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — KRYS vs RGEN

growth of $100 · dividends reinvested · last 9y

KRYS +3047.1% (+46.7%/yr)RGEN +311.4% (+17.0%/yr)KRYS compounded faster over this window

Log scale — wide-divergence pair

KRYS RGEN

KRYS vs RGEN: by the numbers

•RGEN is the larger company ($9.87B vs $9.63B market cap).
•KRYS trades at the lower trailing earnings multiple (40.95 vs 239.53 P/E), one valuation lens rather than an overall verdict.
•KRYS converts more revenue to profit (54.82% vs 5.29% net margin).

Metrics side by side

Valuation

Metric	KRYS	RGEN
P/E ratio	40.95	239.53
Forward P/E	42.96	84.92
P/S ratio	21.87	12.57
P/B ratio	7.09	4.67
EV / EBITDA	45.09	67.03
FCF yield	2.68%	1.12%

Profitability

Metric	KRYS	RGEN
Gross margin	93.34%	51.05%
Operating margin	44.93%	8.32%
Net margin	54.82%	5.29%
ROE	17.77%	1.97%
ROIC	14.41%	1.85%

Growth (annualized)

Metric	KRYS	RGEN
Revenue CAGR (5Y)	N/A	9.08%
EPS CAGR (5Y)	N/A	-5.26%
FCF CAGR (5Y)	N/A	22.49%
Total return CAGR (5Y)	44.28%	-6.86%

Frequently asked

Which has the lower trailing P/E, KRYS or RGEN?: KRYS has the lower trailing P/E: KRYS trades at 40.95 and RGEN at 239.53. P/E is one valuation measure and does not by itself establish which business is cheaper.
Is KRYS or RGEN more profitable?: KRYS runs the higher net margin — KRYS at 54.82% versus RGEN at 5.29%.
How have KRYS and RGEN total returns compared?: Over the past 5 years, KRYS delivered 44.28% and RGEN delivered -6.86% annualized total return. Past performance doesn't predict future results.

Go deeper

Full KRYS analysis Full RGEN analysis Interactive comparison tool

Dig into the metrics

Krystal Biotech P/E ratio Repligen P/E ratio Krystal Biotech ROE Repligen ROE Krystal Biotech operating margin Repligen operating margin Krystal Biotech revenue growth Repligen revenue growth Krystal Biotech free cash flow Repligen free cash flow

Krystal Biotech & Repligen appear in these rankings

Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.