Intuitive Surgical, Inc. (ISRG) vs Stryker Corporation (SYK)

ISRG leads on 10 of 16 compared metrics, though SYK is the cheaper stock.

A side-by-side comparison of Intuitive Surgical, Inc. and Stryker Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 16, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Compare
Intuitive Surgical, Inc. logo
ISRG
Intuitive Surgical, Inc.
$148.26B
$416.55Healthcare
Stryker Corporation logo
SYK
Stryker Corporation
$119.06B
$310.58Healthcare

Total return — ISRG vs SYK

growth of $100 · last 26y
ISRG +20521.2%SYK +1355.4%ISRG compounded faster
Log scale — wide-divergence pair
101001k10k100kStart $10020052010201520202025$20,621$1,455
ISRG SYK

ISRG vs SYK: by the numbers

  • •ISRG is the larger company ($148.26B vs $119.06B market cap).
  • •SYK trades at the lower earnings multiple (35.95 vs 50.49 P/E).
  • •ISRG converts more revenue to profit (28.15% vs 13.21% net margin).
  • •ISRG grew revenue faster over the past five years (18.39% vs 11.42% CAGR).
  • •SYK pays a dividend (1.11% yield) while ISRG does not currently pay one.

Which is better, ISRG or SYK?

Metric tally: ISRG 10 · SYK 6

It depends on what you're optimizing for:

ValueSYK(lower P/E)
GrowthISRG(faster 5Y revenue CAGR)
QualityISRG(higher ROIC)

Metrics side by side

Valuation

MetricISRGSYK
P/E ratio50.4935.95●
Forward P/E35.3818.56●
P/S ratio14.164.75●
P/B ratio8.585.22●
PEG ratio3.17●5.16
EV / EBITDA34.2321.49●
FCF yield1.89%3.81%●

Profitability

MetricISRGSYK
Gross margin66.29%●63.67%
Operating margin30.45%●21.34%
Net margin28.15%●13.21%
ROE17.05%●14.52%
ROIC13.71%●8.53%

Dividends

MetricISRGSYK
Dividend yield—1.11%
Payout ratio—40.52%

Growth (annualized)

MetricISRGSYK
Revenue CAGR (5Y)18.39%●11.42%
EPS CAGR (5Y)21.51%●14.79%
FCF CAGR (5Y)16.61%●11.01%
Total return CAGR (5Y)7.58%●4.98%

Frequently asked

Which is better, ISRG or SYK?
It depends on your goal. value: SYK (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: ISRG (higher ROIC). Across all compared metrics, ISRG leads 10 to 6.
Is ISRG or SYK cheaper?
On trailing earnings, SYK is cheaper: ISRG trades at a 50.49 P/E and SYK at 35.95.
Which has grown faster, ISRG or SYK?
Over the past five years, ISRG grew revenue faster — ISRG at a 18.39% CAGR versus SYK at 11.42%.
Does ISRG or SYK pay a bigger dividend?
SYK pays a dividend (1.11% yield) while ISRG does not currently pay one.
Is ISRG or SYK more profitable?
ISRG runs the higher net margin — ISRG at 28.15% versus SYK at 13.21%.
Which has been the better investment, ISRG or SYK?
Over the past 10-year, ISRG delivered the higher annualized total return — ISRG at 19.33% versus SYK at 11.71%. Past performance doesn't predict future results.

Go deeper

Full ISRG analysisFull SYK analysisInteractive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratioStryker P/E ratioIntuitive Surgical dividend yieldStryker dividend yieldIntuitive Surgical ROEStryker ROEIntuitive Surgical operating marginStryker operating marginIntuitive Surgical revenue growthStryker revenue growthIntuitive Surgical free cash flowStryker free cash flow

Intuitive Surgical & Stryker appear in these rankings

Fastest Revenue Growth StocksHighest Operating Margin StocksBest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 16, 2026.