Intuitive Surgical, Inc. (ISRG) vs Pfizer Inc. (PFE)
A side-by-side comparison of Intuitive Surgical, Inc. and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 29, 2026. Differences are shown without an overall score or investment verdict.
ISRG
Intuitive Surgical, Inc.
$353.10HealthcareDelayed quote: Jul 29, 2026, 4:00 PM EDT
PFE
Pfizer Inc.
$25.15HealthcareDelayed quote: Jul 29, 2026, 4:02 PM EDT
Total return — ISRG vs PFE
growth of $100 · dividends reinvested · last 26yISRG +17722.7%PFE +64.3%ISRG compounded faster
Log scale — wide-divergence pair
ISRG PFE
ISRG vs PFE: by the numbers
- •PFE is the larger company ($143.34B vs $124.74B market cap).
- •PFE trades at the lower trailing earnings multiple (19.27 vs 41.16 P/E), one valuation lens rather than an overall verdict.
- •ISRG converts more revenue to profit (28.45% vs 11.83% net margin).
- •ISRG grew revenue faster over the past five years (16.41% vs 8.22% CAGR).
- •PFE pays a dividend (6.81% yield), while ISRG has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | ISRG | PFE |
|---|---|---|
| P/E ratio | 41.16 | 19.27 |
| Forward P/E | 33.60 | 8.58 |
| P/S ratio | 11.75 | 2.29 |
| P/B ratio | 7.14 | 1.61 |
| PEG ratio | 3.17 | N/A |
| EV / EBITDA | 30.00 | 9.88 |
| FCF yield | 2.48% | 6.55% |
Profitability
| Metric | ISRG | PFE |
|---|---|---|
| Gross margin | 66.68% | 69.35% |
| Operating margin | 31.28% | 23.45% |
| Net margin | 28.45% | 11.83% |
| ROE | 17.28% | 8.31% |
| ROIC | 13.71% | 8.84% |
Dividends
| Metric | ISRG | PFE |
|---|---|---|
| Dividend yield | N/A | 6.81% |
| Payout ratio | N/A | 126.47% |
Growth (annualized)
| Metric | ISRG | PFE |
|---|---|---|
| Revenue CAGR (5Y) | 16.41% | 8.22% |
| EPS CAGR (5Y) | 21.51% | -3.78% |
| FCF CAGR (5Y) | 14.17% | -3.79% |
| Total return CAGR (5Y) | 2.22% | -5.22% |
Frequently asked
- Which has the lower trailing P/E, ISRG or PFE?
- PFE has the lower trailing P/E: ISRG trades at 41.16 and PFE at 19.27. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, ISRG or PFE?
- Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus PFE at 8.22%.
- Does ISRG or PFE pay a bigger dividend?
- PFE pays a dividend (6.81% yield), while ISRG has no payments in the available dividend history.
- Is ISRG or PFE more profitable?
- ISRG runs the higher net margin — ISRG at 28.45% versus PFE at 11.83%.
- How have ISRG and PFE total returns compared?
- Over the past 10 years, ISRG delivered 16.79% and PFE delivered 1.54% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Intuitive Surgical P/E ratioPfizer P/E ratioIntuitive Surgical dividend yieldPfizer dividend yieldIntuitive Surgical ROEPfizer ROEIntuitive Surgical operating marginPfizer operating marginIntuitive Surgical revenue growthPfizer revenue growthIntuitive Surgical free cash flowPfizer free cash flow
Intuitive Surgical & Pfizer appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 29, 2026.