Which has the lower trailing P/E, ISRG or PFE?

PFE has the lower trailing P/E: ISRG trades at 42.00 and PFE at 36.63. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ISRG or PFE?

Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus PFE at 6.29%.

Does ISRG or PFE pay a bigger dividend?

PFE pays a dividend (6.19% yield), while ISRG has no payments in the available dividend history.

Is ISRG or PFE more profitable?

ISRG runs the higher net margin — ISRG at 28.45% versus PFE at 6.81%.

How have ISRG and PFE total returns compared?

Over the past 10 years, ISRG delivered 16.97% and PFE delivered 3.17% annualized total return. Past performance doesn't predict future results.

Intuitive Surgical, Inc. (ISRG) vs Pfizer Inc. (PFE)

A side-by-side comparison of Intuitive Surgical, Inc. and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 10, 2026. Differences are shown without an overall score or investment verdict.

ISRG

Intuitive Surgical, Inc.

$130.41B

$369.15HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

PFE

Pfizer Inc.

$157.99B

$27.72HealthcareDelayed quote: Sep 11, 2026, 4:01 PM EDT

Total return — ISRG vs PFE

growth of $100 · dividends reinvested · last 10y

ISRG +359.2% (+16.5%/yr)PFE +37.3% (+3.2%/yr)ISRG compounded faster over this window

ISRG PFE

ISRG vs PFE: by the numbers

•PFE is the larger company ($157.99B vs $130.41B market cap).
•PFE trades at the lower trailing earnings multiple (36.63 vs 42.00 P/E), one valuation lens rather than an overall verdict.
•ISRG converts more revenue to profit (28.45% vs 6.81% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 6.29% CAGR).
•PFE pays a dividend (6.19% yield), while ISRG has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	ISRG	PFE
P/E ratio	42.00	36.63
Forward P/E	34.18	9.32
P/S ratio	11.82	2.48
P/B ratio	7.18	1.85
EV / EBITDA	30.16	10.15
FCF yield	2.47%	6.95%

Profitability

Metric	ISRG	PFE
Gross margin	66.68%	71.32%
Operating margin	31.28%	25.08%
Net margin	28.45%	6.81%
ROE	17.28%	5.09%
ROIC	15.11%	9.33%

Dividends

Metric	ISRG	PFE
Dividend yield	N/A	6.19%
Payout ratio	N/A	227.27%

Growth (annualized)

Metric	ISRG	PFE
Revenue CAGR (5Y)	16.41%	6.29%
EPS CAGR (5Y)	21.51%	-3.78%
FCF CAGR (5Y)	14.17%	-3.11%
Total return CAGR (5Y)	1.11%	-4.68%

Frequently asked

Which has the lower trailing P/E, ISRG or PFE?: PFE has the lower trailing P/E: ISRG trades at 42.00 and PFE at 36.63. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ISRG or PFE?: Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus PFE at 6.29%.
Does ISRG or PFE pay a bigger dividend?: PFE pays a dividend (6.19% yield), while ISRG has no payments in the available dividend history.
Is ISRG or PFE more profitable?: ISRG runs the higher net margin — ISRG at 28.45% versus PFE at 6.81%.
How have ISRG and PFE total returns compared?: Over the past 10 years, ISRG delivered 16.97% and PFE delivered 3.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ISRG analysis Full PFE analysis Interactive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratio Pfizer P/E ratio Pfizer dividend yield Intuitive Surgical ROE Pfizer ROE Intuitive Surgical operating margin Pfizer operating margin Intuitive Surgical revenue growth Pfizer revenue growth Intuitive Surgical free cash flow Pfizer free cash flow

Intuitive Surgical & Pfizer appear in these rankings

Highest Dividend Yield Stocks Fastest Revenue Growth Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 10, 2026.