Intuitive Surgical, Inc. (ISRG) vs Pfizer Inc. (PFE)

ISRG leads on 8 of 15 compared metrics, though PFE is the cheaper stock.

A side-by-side comparison of Intuitive Surgical, Inc. and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 13, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Intuitive Surgical, Inc. logo
ISRG
Intuitive Surgical, Inc.
$145.58B
$411.06Healthcare
Pfizer Inc. logo
PFE
Pfizer Inc.
$149.38B
$26.21Healthcare

Total return — ISRG vs PFE

growth of $100 · last 26y
ISRG +20149.3%PFE -42.3%ISRG compounded faster
Log scale — wide-divergence pair
101001k10k100kStart $10020052010201520202025$20,249$58
ISRG PFE

ISRG vs PFE: by the numbers

  • •PFE is the larger company ($149.38B vs $145.58B market cap).
  • •PFE trades at the lower earnings multiple (20.01 vs 49.83 P/E).
  • •ISRG converts more revenue to profit (28.15% vs 11.83% net margin).
  • •ISRG grew revenue faster over the past five years (18.39% vs 8.22% CAGR).
  • •PFE pays a dividend (6.56% yield) while ISRG does not currently pay one.

Which is better, ISRG or PFE?

Metric tally: ISRG 8 · PFE 7

It depends on what you're optimizing for:

ValuePFE(lower P/E)
GrowthISRG(faster 5Y revenue CAGR)
QualityISRG(higher ROIC)

Valuation

MetricISRGPFE
P/E ratio49.8320.01●
Forward P/E34.909.25●
P/S ratio13.982.37●
P/B ratio8.461.67●
PEG ratio3.17—
EV / EBITDA35.4112.72●
FCF yield1.92%6.31%●

Profitability

MetricISRGPFE
Gross margin66.29%69.35%●
Operating margin30.45%●23.45%
Net margin28.15%●11.83%
ROE17.05%●8.31%
ROIC13.71%●8.84%

Dividends

MetricISRGPFE
Dividend yield—6.56%
Payout ratio—126.47%

Growth (annualized)

MetricISRGPFE
Revenue CAGR (5Y)18.39%●8.22%
EPS CAGR (5Y)21.51%●-3.78%
FCF CAGR (5Y)16.61%●-3.79%
Total return CAGR (5Y)7.37%●-3.33%

Frequently asked

Which is better, ISRG or PFE?
It depends on your goal. value: PFE (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: ISRG (higher ROIC). Across all compared metrics, ISRG leads 8 to 7.
Is ISRG or PFE cheaper?
On trailing earnings, PFE is cheaper: ISRG trades at a 49.83 P/E and PFE at 20.01.
Which has grown faster, ISRG or PFE?
Over the past five years, ISRG grew revenue faster — ISRG at a 18.39% CAGR versus PFE at 8.22%.
Does ISRG or PFE pay a bigger dividend?
PFE pays a dividend (6.56% yield) while ISRG does not currently pay one.
Is ISRG or PFE more profitable?
ISRG runs the higher net margin — ISRG at 28.15% versus PFE at 11.83%.
Which has been the better investment, ISRG or PFE?
Over the past 10-year, ISRG delivered the higher annualized total return — ISRG at 19.14% versus PFE at 2.13%. Past performance doesn't predict future results.

Go deeper

Full ISRG analysisFull PFE analysisInteractive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratioPfizer P/E ratioIntuitive Surgical dividend yieldPfizer dividend yieldIntuitive Surgical ROEPfizer ROEIntuitive Surgical operating marginPfizer operating marginIntuitive Surgical revenue growthPfizer revenue growthIntuitive Surgical free cash flowPfizer free cash flow

Intuitive Surgical & Pfizer appear in these rankings

Highest Dividend Yield StocksFastest Revenue Growth StocksHighest Operating Margin StocksHighest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 13, 2026.