Intuitive Surgical, Inc. (ISRG) vs Novo Nordisk A/S (NVO)
A side-by-side comparison of Intuitive Surgical, Inc. and Novo Nordisk A/S across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 13, 2026. Differences are shown without an overall score or investment verdict.
ISRG
Intuitive Surgical, Inc.
$393.33HealthcareDelayed quote: Sep 18, 2026, 4:00 PM EDT
NVO
Novo Nordisk A/S
$43.24HealthcareDelayed quote: Sep 18, 2026, 4:00 PM EDT
Total return — ISRG vs NVO
growth of $100 · dividends reinvested · last 10yISRG +384.1% (+17.1%/yr)NVO +135.8% (+9.0%/yr)ISRG compounded faster over this window
ISRG NVO
ISRG vs NVO: by the numbers
- •NVO is the larger company ($192.01B vs $138.95B market cap).
- •NVO trades at the lower trailing earnings multiple (10.66 vs 44.75 P/E), one valuation lens rather than an overall verdict.
- •NVO converts more revenue to profit (35.33% vs 28.45% net margin).
- •NVO grew revenue faster over the past five years (19.76% vs 16.41% CAGR).
- •NVO pays a dividend (4.17% yield), while ISRG has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | ISRG | NVO |
|---|---|---|
| P/E ratio | 44.75 | 10.66 |
| Forward P/E | 36.42 | N/A |
| P/S ratio | 12.59 | 3.76 |
| P/B ratio | 7.65 | 5.69 |
| EV / EBITDA | 32.18 | 7.88 |
| FCF yield | 2.32% | 3.88% |
Profitability
| Metric | ISRG | NVO |
|---|---|---|
| Gross margin | 66.68% | 80.64% |
| Operating margin | 31.28% | 43.10% |
| Net margin | 28.45% | 35.33% |
| ROE | 17.28% | 53.50% |
| ROIC | 15.11% | 30.21% |
Dividends
| Metric | ISRG | NVO |
|---|---|---|
| Dividend yield | N/A | 4.17% |
| Payout ratio | N/A | 44.27% |
Growth (annualized)
| Metric | ISRG | NVO |
|---|---|---|
| Revenue CAGR (5Y) | 16.41% | 19.76% |
| EPS CAGR (5Y) | 21.51% | 19.59% |
| FCF CAGR (5Y) | 14.17% | -1.45% |
| Total return CAGR (5Y) | 1.59% | -0.65% |
Frequently asked
- Which has the lower trailing P/E, ISRG or NVO?
- NVO has the lower trailing P/E: ISRG trades at 44.75 and NVO at 10.66. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, ISRG or NVO?
- Over the past five years, NVO grew revenue faster — ISRG at a 16.41% CAGR versus NVO at 19.76%.
- Does ISRG or NVO pay a bigger dividend?
- NVO pays a dividend (4.17% yield), while ISRG has no payments in the available dividend history.
- Is ISRG or NVO more profitable?
- NVO runs the higher net margin — ISRG at 28.45% versus NVO at 35.33%.
- How have ISRG and NVO total returns compared?
- Over the past 10 years, ISRG delivered 17.25% and NVO delivered 9.46% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Intuitive Surgical P/E ratioNovo Nordisk A/S P/E ratioNovo Nordisk A/S dividend yieldIntuitive Surgical ROENovo Nordisk A/S ROEIntuitive Surgical operating marginNovo Nordisk A/S operating marginIntuitive Surgical revenue growthNovo Nordisk A/S revenue growthIntuitive Surgical free cash flowNovo Nordisk A/S free cash flow
Intuitive Surgical & Novo Nordisk A/S appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 13, 2026.