Which has the lower trailing P/E, ISRG or MCK?

MCK has the lower trailing P/E: ISRG trades at 42.07 and MCK at 24.66. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ISRG or MCK?

Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus MCK at 10.88%.

Does ISRG or MCK pay a bigger dividend?

MCK pays a dividend (0.36% yield), while ISRG has no payments in the available dividend history.

Is ISRG or MCK more profitable?

ISRG runs the higher net margin — ISRG at 28.45% versus MCK at 1.12%.

How have ISRG and MCK total returns compared?

Over the past 10 years, ISRG delivered 17.07% and MCK delivered 18.44% annualized total return. Past performance doesn't predict future results.

Intuitive Surgical, Inc. (ISRG) vs McKesson Corporation (MCK)

A side-by-side comparison of Intuitive Surgical, Inc. and McKesson Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 4, 2026. Differences are shown without an overall score or investment verdict.

ISRG

Intuitive Surgical, Inc.

$129.55B

$366.70HealthcareDelayed quote: Sep 4, 2026, 4:00 PM EDT

MCK

McKesson Corporation

$106.31B

$907.99HealthcareDelayed quote: Sep 4, 2026, 4:00 PM EDT

Total return — ISRG vs MCK

growth of $100 · dividends reinvested · last 10y

ISRG +382.4% (+17.0%/yr)MCK +444.8% (+18.5%/yr)MCK compounded faster over this window

ISRG MCK

ISRG vs MCK: by the numbers

•ISRG is the larger company ($129.55B vs $106.31B market cap).
•MCK trades at the lower trailing earnings multiple (24.66 vs 42.07 P/E), one valuation lens rather than an overall verdict.
•ISRG converts more revenue to profit (28.45% vs 1.12% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 10.88% CAGR).
•MCK pays a dividend (0.36% yield), while ISRG has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	ISRG	MCK
P/E ratio	42.07	24.66
Forward P/E	34.25	23.62
P/S ratio	12.02	0.27
P/B ratio	7.30	N/A
EV / EBITDA	30.68	15.68
FCF yield	2.43%	5.63%

Profitability

Metric	ISRG	MCK
Gross margin	66.68%	3.64%
Operating margin	31.28%	1.62%
Net margin	28.45%	1.12%
ROE	17.28%	-219.24%
ROIC	15.11%	28.34%

Dividends

Metric	ISRG	MCK
Dividend yield	N/A	0.36%
Payout ratio	N/A	8.51%

Growth (annualized)

Metric	ISRG	MCK
Revenue CAGR (5Y)	16.41%	10.88%
EPS CAGR (5Y)	21.51%	40.71%
FCF CAGR (5Y)	14.17%	13.40%
Total return CAGR (5Y)	0.69%	35.60%

Frequently asked

Which has the lower trailing P/E, ISRG or MCK?: MCK has the lower trailing P/E: ISRG trades at 42.07 and MCK at 24.66. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ISRG or MCK?: Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus MCK at 10.88%.
Does ISRG or MCK pay a bigger dividend?: MCK pays a dividend (0.36% yield), while ISRG has no payments in the available dividend history.
Is ISRG or MCK more profitable?: ISRG runs the higher net margin — ISRG at 28.45% versus MCK at 1.12%.
How have ISRG and MCK total returns compared?: Over the past 10 years, ISRG delivered 17.07% and MCK delivered 18.44% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ISRG analysis Full MCK analysis Interactive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratio McKesson P/E ratio McKesson dividend yield Intuitive Surgical ROE McKesson ROE Intuitive Surgical operating margin McKesson operating margin Intuitive Surgical revenue growth McKesson revenue growth Intuitive Surgical free cash flow McKesson free cash flow

Intuitive Surgical & McKesson appear in these rankings

Fastest Revenue Growth Stocks Highest ROIC Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 4, 2026.