How have IRTC and XENE total returns compared?

Over the past 5 years, IRTC delivered 12.95% and XENE delivered 4.61% annualized total return. Past performance doesn't predict future results.

iRhythm Technologies, Inc. (IRTC) vs Xenon Pharmaceuticals Inc. (XENE)

A side-by-side comparison of iRhythm Technologies, Inc. and Xenon Pharmaceuticals Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

IRTC

iRhythm Technologies, Inc.

$3.55B

$108.08HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT

XENE

Xenon Pharmaceuticals Inc.

$3.50B

$36.22HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT

Total return — IRTC vs XENE

growth of $100 · dividends reinvested · last 10y

IRTC +318.8% (+15.4%/yr)XENE +355.4% (+16.4%/yr)XENE compounded faster over this window

IRTC XENE

IRTC vs XENE: by the numbers

•IRTC is the larger company ($3.55B vs $3.50B market cap).
•Both run net losses; IRTC's is the smaller (-1.69% vs -4612.13% net margin).

Metrics side by side

Valuation

Metric	IRTC	XENE
P/S ratio	4.30	N/A
P/B ratio	19.10	2.82
EV / EBITDA	288.41	N/A
FCF yield	1.10%	N/A

Profitability

Metric	IRTC	XENE
Gross margin	71.45%	66.09%
Operating margin	-1.17%	-4974.27%
Net margin	-1.69%	-4612.13%
ROE	-7.50%	-32.94%
ROIC	-1.07%	-35.27%

Growth (annualized)

Metric	IRTC	XENE
Revenue CAGR (5Y)	21.93%	N/A
Total return CAGR (5Y)	12.95%	4.61%

Frequently asked

How have IRTC and XENE total returns compared?: Over the past 5 years, IRTC delivered 12.95% and XENE delivered 4.61% annualized total return. Past performance doesn't predict future results.

Go deeper

Full IRTC analysis Full XENE analysis Interactive comparison tool

Dig into the metrics

iRhythm Technologies ROE Xenon Pharmaceuticals ROE iRhythm Technologies operating margin Xenon Pharmaceuticals operating margin iRhythm Technologies revenue growth Xenon Pharmaceuticals revenue growth iRhythm Technologies free cash flow Xenon Pharmaceuticals free cash flow

iRhythm Technologies & Xenon Pharmaceuticals appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.