How have IOVA and PTCT total returns compared?

Over the past 10 years, IOVA delivered 5.84% and PTCT delivered 16.60% annualized total return. Past performance doesn't predict future results.

Iovance Biotherapeutics, Inc. (IOVA) vs PTC Therapeutics, Inc. (PTCT)

A side-by-side comparison of Iovance Biotherapeutics, Inc. and PTC Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

IOVA

Iovance Biotherapeutics, Inc.

$5.82B

$13.03HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

PTCT

PTC Therapeutics, Inc.

$5.29B

$63.33HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

Total return — IOVA vs PTCT

growth of $100 · dividends reinvested · last 10y

IOVA +87.7% (+6.5%/yr)PTCT +377.1% (+16.9%/yr)PTCT compounded faster over this window

IOVA PTCT

IOVA vs PTCT: by the numbers

•IOVA is the larger company ($5.82B vs $5.29B market cap).
•Both run net losses; PTCT's is the smaller (-3.80% vs -89.09% net margin).

Metrics side by side

Valuation

Metric	IOVA	PTCT
Forward P/E	N/A	49.84
P/S ratio	17.90	5.24
P/B ratio	7.90	N/A
EV / EBITDA	N/A	28.75

Profitability

Metric	IOVA	PTCT
Gross margin	97.23%	95.85%
Operating margin	-153.08%	49.49%
Net margin	-89.09%	-3.80%
ROE	-39.33%	N/A
ROIC	-37.26%	4.59%

Growth (annualized)

Metric	IOVA	PTCT
Revenue CAGR (5Y)	N/A	16.41%
Total return CAGR (5Y)	-11.55%	11.75%

Frequently asked

How have IOVA and PTCT total returns compared?: Over the past 10 years, IOVA delivered 5.84% and PTCT delivered 16.60% annualized total return. Past performance doesn't predict future results.

Go deeper

Full IOVA analysis Full PTCT analysis Interactive comparison tool

Dig into the metrics

Iovance Biotherapeutics ROE PTC Therapeutics ROE Iovance Biotherapeutics operating margin PTC Therapeutics operating margin Iovance Biotherapeutics revenue growth PTC Therapeutics revenue growth Iovance Biotherapeutics free cash flow PTC Therapeutics free cash flow

Iovance Biotherapeutics & PTC Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.