Iovance Biotherapeutics, Inc. (IOVA) vs Ligand Pharmaceuticals Incorporated (LGND)
A side-by-side comparison of Iovance Biotherapeutics, Inc. and Ligand Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
IOVA
Iovance Biotherapeutics, Inc.
$13.25HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
LGND
Ligand Pharmaceuticals Incorporated
$296.60HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
Total return — IOVA vs LGND
growth of $100 · dividends reinvested · last 10yIOVA +87.7% (+6.5%/yr)LGND +389.0% (+17.2%/yr)LGND compounded faster over this window
IOVA LGND
IOVA vs LGND: by the numbers
- •LGND is the larger company ($5.94B vs $5.92B market cap).
- •LGND is profitable (67.88% net margin) while IOVA runs a net loss (-89.09%).
Metrics side by side
Valuation
| Metric | IOVA | LGND |
|---|---|---|
| P/E ratio | N/A | 31.72 |
| Forward P/E | N/A | 31.87 |
| P/S ratio | 18.21 | 20.46 |
| P/B ratio | 8.04 | 6.14 |
| EV / EBITDA | N/A | 44.97 |
| FCF yield | N/A | 2.21% |
Profitability
| Metric | IOVA | LGND |
|---|---|---|
| Gross margin | 97.23% | 98.58% |
| Operating margin | -153.08% | 17.61% |
| Net margin | -89.09% | 67.88% |
| ROE | -39.33% | 20.38% |
| ROIC | -37.26% | 3.91% |
Growth (annualized)
| Metric | IOVA | LGND |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 2.92% |
| FCF CAGR (5Y) | N/A | -0.49% |
| Total return CAGR (5Y) | -11.55% | 30.72% |
Frequently asked
- Is IOVA or LGND more profitable?
- LGND runs the higher net margin — IOVA at -89.09% versus LGND at 67.88%.
- How have IOVA and LGND total returns compared?
- Over the past 10 years, IOVA delivered 5.84% and LGND delivered 17.12% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Ligand Pharmaceuticals P/E ratioIovance Biotherapeutics ROELigand Pharmaceuticals ROEIovance Biotherapeutics operating marginLigand Pharmaceuticals operating marginIovance Biotherapeutics revenue growthLigand Pharmaceuticals revenue growthIovance Biotherapeutics free cash flowLigand Pharmaceuticals free cash flow
Iovance Biotherapeutics & Ligand Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.