Iovance Biotherapeutics, Inc. (IOVA) vs Kiniksa Pharmaceuticals International, plc (KNSA)
A side-by-side comparison of Iovance Biotherapeutics, Inc. and Kiniksa Pharmaceuticals International, plc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
IOVA
Iovance Biotherapeutics, Inc.
$13.08HealthcareDelayed quote: Oct 6, 2026, 10:40 AM EDT
KNSA
Kiniksa Pharmaceuticals International, plc
$74.09HealthcareDelayed quote: Oct 6, 2026, 10:40 AM EDT
Total return — IOVA vs KNSA
growth of $100 · dividends reinvested · last 8yIOVA -16.5% (-2.2%/yr)KNSA +291.9% (+18.6%/yr)KNSA compounded faster over this window
IOVA KNSA
IOVA vs KNSA: by the numbers
- •IOVA is the larger company ($5.84B vs $5.65B market cap).
- •KNSA is profitable (9.59% net margin) while IOVA runs a net loss (-89.09%).
Metrics side by side
Valuation
| Metric | IOVA | KNSA |
|---|---|---|
| P/E ratio | N/A | 75.60 |
| Forward P/E | N/A | 53.20 |
| P/S ratio | 17.96 | 6.71 |
| P/B ratio | 7.93 | 8.63 |
| EV / EBITDA | N/A | 53.70 |
| FCF yield | N/A | 3.24% |
Profitability
| Metric | IOVA | KNSA |
|---|---|---|
| Gross margin | 97.23% | 54.49% |
| Operating margin | -153.08% | 11.92% |
| Net margin | -89.09% | 9.59% |
| ROE | -39.33% | 12.33% |
| ROIC | -37.26% | 9.76% |
Growth (annualized)
| Metric | IOVA | KNSA |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 155.66% |
| Total return CAGR (5Y) | -11.55% | 47.48% |
Frequently asked
- Is IOVA or KNSA more profitable?
- KNSA runs the higher net margin — IOVA at -89.09% versus KNSA at 9.59%.
- How have IOVA and KNSA total returns compared?
- Over the past 5 years, IOVA delivered -11.55% and KNSA delivered 47.48% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Kiniksa Pharmaceuticals International P/E ratioIovance Biotherapeutics ROEKiniksa Pharmaceuticals International ROEIovance Biotherapeutics operating marginKiniksa Pharmaceuticals International operating marginIovance Biotherapeutics revenue growthKiniksa Pharmaceuticals International revenue growthIovance Biotherapeutics free cash flowKiniksa Pharmaceuticals International free cash flow
Iovance Biotherapeutics & Kiniksa Pharmaceuticals International appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.