Innoviva, Inc. (INVA) vs Septerna Inc (SEPN)

A side-by-side comparison of Innoviva, Inc. and Septerna Inc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Innoviva, Inc. logo
INVA
Innoviva, Inc.
$1.54B
$20.90HealthcareDelayed quote: Oct 6, 2026, 2:50 PM EDT
Septerna Inc logo
SEPN
Septerna Inc
$1.63B
$36.15HealthcareDelayed quote: Oct 6, 2026, 2:44 PM EDT

Total return — INVA vs SEPN

growth of $100 · dividends reinvested · last 2y
INVA +3.4% (+1.7%/yr)SEPN +77.0% (+33.0%/yr)SEPN compounded faster over this window
50100150200Start $10020252026$103$177
INVA SEPN

INVA vs SEPN: by the numbers

  • •SEPN is the larger company ($1.63B vs $1.54B market cap).
  • •INVA is profitable (80.56% net margin) while SEPN runs a net loss (-24.51%).

Metrics side by side

Valuation

MetricINVASEPN
P/E ratio5.10N/A
Forward P/E8.64N/A
PEG ratio0.49N/A
P/S ratio3.4816.48
P/B ratio1.254.21
EV / EBITDA4.92N/A
FCF yield12.21%6.45%

Profitability

MetricINVASEPN
Gross margin73.09%99.57%
Operating margin36.66%-175.83%
Net margin80.56%-24.51%
ROE28.97%-6.27%
ROIC8.36%-8.93%

Growth (annualized)

MetricINVASEPN
Revenue CAGR (5Y)3.94%N/A
EPS CAGR (5Y)12.71%N/A
FCF CAGR (5Y)-10.54%N/A
Total return CAGR (5Y)4.52%N/A

Frequently asked

Is INVA or SEPN more profitable?
INVA runs the higher net margin — INVA at 80.56% versus SEPN at -24.51%.

Go deeper

Full INVA analysisFull SEPN analysisInteractive comparison tool

Dig into the metrics

Innoviva P/E ratioInnoviva ROESepterna ROEInnoviva operating marginSepterna operating marginInnoviva revenue growthSepterna revenue growthInnoviva free cash flowSepterna free cash flow

Innoviva & Septerna appear in these rankings

Highest ROE StocksHighest Operating Margin StocksHighest FCF Yield StocksLowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.