Is INVA or MAZE more profitable?

INVA runs the higher net margin — INVA at 80.56% versus MAZE at -667.95%.

Innoviva, Inc. (INVA) vs Maze Therapeutics, Inc. (MAZE)

A side-by-side comparison of Innoviva, Inc. and Maze Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

INVA

Innoviva, Inc.

$1.54B

$20.87HealthcareDelayed quote: Oct 6, 2026, 11:05 AM EDT

MAZE

Maze Therapeutics, Inc.

$1.46B

$26.47HealthcareDelayed quote: Oct 6, 2026, 11:05 AM EDT

Total return — INVA vs MAZE

growth of $100 · dividends reinvested · last 2y

INVA +9.3% (+4.5%/yr)MAZE +65.7% (+28.7%/yr)MAZE compounded faster over this window

INVA MAZE

INVA vs MAZE: by the numbers

•INVA is the larger company ($1.54B vs $1.46B market cap).
•INVA is profitable (80.56% net margin) while MAZE runs a net loss (-667.95%).

Metrics side by side

Valuation

Metric	INVA	MAZE
P/E ratio	5.09	N/A
Forward P/E	8.62	N/A
PEG ratio	0.49	N/A
P/S ratio	3.47	73.25
P/B ratio	1.25	3.23
EV / EBITDA	4.91	N/A
FCF yield	12.23%	N/A

Profitability

Metric	INVA	MAZE
Gross margin	73.09%	0.00%
Operating margin	36.66%	0.00%
Net margin	80.56%	-667.95%
ROE	28.97%	-29.48%
ROIC	8.36%	-28.63%

Growth (annualized)

Metric	INVA	MAZE
Revenue CAGR (5Y)	3.94%	N/A
EPS CAGR (5Y)	12.71%	N/A
FCF CAGR (5Y)	-10.54%	N/A
Total return CAGR (5Y)	4.52%	N/A

Frequently asked

Is INVA or MAZE more profitable?: INVA runs the higher net margin — INVA at 80.56% versus MAZE at -667.95%.

Go deeper

Full INVA analysis Full MAZE analysis Interactive comparison tool

Dig into the metrics

Innoviva P/E ratio Innoviva ROE Maze Therapeutics ROE Innoviva operating margin Maze Therapeutics operating margin Innoviva revenue growth Maze Therapeutics revenue growth Innoviva free cash flow Maze Therapeutics free cash flow

Innoviva & Maze Therapeutics appear in these rankings

Highest ROE Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.