Which has the lower trailing P/E, INSP or TMDX?

INSP has the lower trailing P/E: INSP trades at 15.14 and TMDX at 20.67. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, INSP or TMDX?

Over the past five years, TMDX grew revenue faster — INSP at a 38.69% CAGR versus TMDX at 86.12%.

Is INSP or TMDX more profitable?

TMDX runs the higher net margin — INSP at 15.03% versus TMDX at 22.69%.

How have INSP and TMDX total returns compared?

Over the past 5 years, INSP delivered -21.78% and TMDX delivered 19.54% annualized total return. Past performance doesn't predict future results.

Inspire Medical Systems, Inc. (INSP) vs TransMedics Group, Inc. (TMDX)

A side-by-side comparison of Inspire Medical Systems, Inc. and TransMedics Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 4, 2026. Differences are shown without an overall score or investment verdict.

INSP

Inspire Medical Systems, Inc.

$2.02B

$69.97HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

TMDX

TransMedics Group, Inc.

$2.76B

$79.80HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

Total return — INSP vs TMDX

growth of $100 · dividends reinvested · last 7y

INSP +39.7% (+4.9%/yr)TMDX +256.9% (+19.9%/yr)TMDX compounded faster over this window

INSP TMDX

INSP vs TMDX: by the numbers

•TMDX is the larger company ($2.76B vs $2.02B market cap).
•INSP trades at the lower trailing earnings multiple (15.14 vs 20.67 P/E), one valuation lens rather than an overall verdict.
•TMDX converts more revenue to profit (22.69% vs 15.03% net margin).
•TMDX grew revenue faster over the past five years (86.12% vs 38.69% CAGR).

Metrics side by side

Valuation

Metric	INSP	TMDX
P/E ratio	15.14	20.67
Forward P/E	58.58	54.40
P/S ratio	2.25	4.13
P/B ratio	2.45	5.32
EV / EBITDA	26.98	26.71
FCF yield	5.79%	2.87%

Profitability

Metric	INSP	TMDX
Gross margin	86.13%	58.69%
Operating margin	6.02%	12.21%
Net margin	15.03%	22.69%
ROE	16.36%	29.28%
ROIC	6.33%	5.87%

Growth (annualized)

Metric	INSP	TMDX
Revenue CAGR (5Y)	38.69%	86.12%
Total return CAGR (5Y)	-21.78%	19.54%

Frequently asked

Which has the lower trailing P/E, INSP or TMDX?: INSP has the lower trailing P/E: INSP trades at 15.14 and TMDX at 20.67. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, INSP or TMDX?: Over the past five years, TMDX grew revenue faster — INSP at a 38.69% CAGR versus TMDX at 86.12%.
Is INSP or TMDX more profitable?: TMDX runs the higher net margin — INSP at 15.03% versus TMDX at 22.69%.
How have INSP and TMDX total returns compared?: Over the past 5 years, INSP delivered -21.78% and TMDX delivered 19.54% annualized total return. Past performance doesn't predict future results.

Go deeper

Full INSP analysis Full TMDX analysis Interactive comparison tool

Dig into the metrics

Inspire Medical Systems P/E ratio TransMedics P/E ratio Inspire Medical Systems ROE TransMedics ROE Inspire Medical Systems operating margin TransMedics operating margin Inspire Medical Systems revenue growth TransMedics revenue growth Inspire Medical Systems free cash flow TransMedics free cash flow

Inspire Medical Systems & TransMedics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 4, 2026.