Which has grown faster, INSP or NTLA?

Over the past five years, INSP grew revenue faster — INSP at a 38.69% CAGR versus NTLA at 7.31%.

Is INSP or NTLA more profitable?

INSP runs the higher net margin — INSP at 15.03% versus NTLA at -672.16%.

How have INSP and NTLA total returns compared?

Over the past 5 years, INSP delivered -21.78% and NTLA delivered -38.01% annualized total return. Past performance doesn't predict future results.

Inspire Medical Systems, Inc. (INSP) vs Intellia Therapeutics, Inc. (NTLA)

A side-by-side comparison of Inspire Medical Systems, Inc. and Intellia Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 4, 2026. Differences are shown without an overall score or investment verdict.

INSP

Inspire Medical Systems, Inc.

$2.02B

$69.97HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

NTLA

Intellia Therapeutics, Inc.

$1.71B

$12.26HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

Total return — INSP vs NTLA

growth of $100 · dividends reinvested · last 8y

INSP +180.1% (+13.7%/yr)NTLA -42.3% (-6.6%/yr)INSP compounded faster over this window

INSP NTLA

INSP vs NTLA: by the numbers

•INSP is the larger company ($2.02B vs $1.71B market cap).
•INSP is profitable (15.03% net margin) while NTLA runs a net loss (-672.16%).
•INSP grew revenue faster over the past five years (38.69% vs 7.31% CAGR).

Metrics side by side

Valuation

Metric	INSP	NTLA
P/E ratio	15.14	N/A
Forward P/E	58.58	N/A
P/S ratio	2.25	28.79
P/B ratio	2.45	2.35
EV / EBITDA	26.98	N/A
FCF yield	5.79%	N/A

Profitability

Metric	INSP	NTLA
Gross margin	86.13%	76.47%
Operating margin	6.02%	-651.67%
Net margin	15.03%	-672.16%
ROE	16.36%	-54.96%
ROIC	6.33%	-54.45%

Growth (annualized)

Metric	INSP	NTLA
Revenue CAGR (5Y)	38.69%	7.31%
Total return CAGR (5Y)	-21.78%	-38.01%

Frequently asked

Which has grown faster, INSP or NTLA?: Over the past five years, INSP grew revenue faster — INSP at a 38.69% CAGR versus NTLA at 7.31%.
Is INSP or NTLA more profitable?: INSP runs the higher net margin — INSP at 15.03% versus NTLA at -672.16%.
How have INSP and NTLA total returns compared?: Over the past 5 years, INSP delivered -21.78% and NTLA delivered -38.01% annualized total return. Past performance doesn't predict future results.

Go deeper

Full INSP analysis Full NTLA analysis Interactive comparison tool

Dig into the metrics

Inspire Medical Systems P/E ratio Inspire Medical Systems ROE Intellia Therapeutics ROE Inspire Medical Systems operating margin Intellia Therapeutics operating margin Inspire Medical Systems revenue growth Intellia Therapeutics revenue growth Inspire Medical Systems free cash flow Intellia Therapeutics free cash flow

Inspire Medical Systems & Intellia Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 4, 2026.