Inspire Medical Systems, Inc. (INSP) vs Mineralys Therapeutics, Inc. (MLYS)

A side-by-side comparison of Inspire Medical Systems, Inc. and Mineralys Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Inspire Medical Systems, Inc. logo
INSP
Inspire Medical Systems, Inc.
$2.01B
$69.41HealthcareDelayed quote: Oct 6, 2026, 11:54 AM EDT
Mineralys Therapeutics, Inc. logo
MLYS
Mineralys Therapeutics, Inc.
$2.01B
$22.81HealthcareDelayed quote: Oct 6, 2026, 11:55 AM EDT

Total return — INSP vs MLYS

growth of $100 · dividends reinvested · last 4y
INSP -73.6% (-28.3%/yr)MLYS +26.4% (+6.0%/yr)MLYS compounded faster over this window
050100150200250Start $100202420252026$26$126
INSP MLYS

INSP vs MLYS: by the numbers

  • •MLYS is the larger company ($2.01B vs $2.01B market cap).
  • •INSP is profitable (15.03% net margin) while MLYS runs a net loss (0.00%).

Metrics side by side

Valuation

MetricINSPMLYS
P/E ratio15.02N/A
Forward P/E58.12N/A
P/S ratio2.23N/A
P/B ratio2.433.65
EV / EBITDA26.75N/A
FCF yield5.84%N/A

Profitability

MetricINSPMLYS
Gross margin86.13%0.00%
Operating margin6.02%0.00%
Net margin15.03%0.00%
ROE16.36%-63.45%
ROIC6.33%-57.17%

Growth (annualized)

MetricINSPMLYS
Revenue CAGR (5Y)38.69%N/A
Total return CAGR (5Y)-21.38%N/A

Frequently asked

Is INSP or MLYS more profitable?
INSP runs the higher net margin — INSP at 15.03% versus MLYS at 0.00%.

Go deeper

Full INSP analysisFull MLYS analysisInteractive comparison tool

Dig into the metrics

Inspire Medical Systems P/E ratioInspire Medical Systems ROEMineralys Therapeutics ROEInspire Medical Systems operating marginMineralys Therapeutics operating marginInspire Medical Systems revenue growthMineralys Therapeutics revenue growthInspire Medical Systems free cash flowMineralys Therapeutics free cash flow

Inspire Medical Systems & Mineralys Therapeutics appear in these rankings

Fastest Revenue Growth StocksHighest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.