Is ICLR or MDGL more profitable?

ICLR runs the higher net margin — ICLR at 3.99% versus MDGL at -25.32%.

How have ICLR and MDGL total returns compared?

Over the past 10 years, ICLR delivered 8.07% and MDGL delivered 41.50% annualized total return. Past performance doesn't predict future results.

ICON Public Limited Company (ICLR) vs Madrigal Pharmaceuticals, Inc. (MDGL)

A side-by-side comparison of ICON Public Limited Company and Madrigal Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ICLR

ICON Public Limited Company

$12.41B

$162.03HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT

MDGL

Madrigal Pharmaceuticals, Inc.

$11.47B

$496.61HealthcareDelayed quote: Oct 6, 2026, 1:49 PM EDT

Total return — ICLR vs MDGL

growth of $100 · dividends reinvested · last 10y

ICLR +121.1% (+8.3%/yr)MDGL +2930.2% (+40.7%/yr)MDGL compounded faster over this window

Log scale — wide-divergence pair

ICLR MDGL

ICLR vs MDGL: by the numbers

•ICLR is the larger company ($12.41B vs $11.47B market cap).
•ICLR is profitable (3.99% net margin) while MDGL runs a net loss (-25.32%).

Metrics side by side

Valuation

Metric	ICLR	MDGL
P/E ratio	38.03	N/A
Forward P/E	15.30	N/A
P/S ratio	1.50	8.94
P/B ratio	1.32	21.91
EV / EBITDA	10.59	N/A
FCF yield	10.85%	N/A

Profitability

Metric	ICLR	MDGL
Gross margin	21.85%	91.48%
Operating margin	10.15%	-25.13%
Net margin	3.99%	-25.32%
ROE	3.51%	-62.07%
ROIC	4.80%	-37.02%

Growth (annualized)

Metric	ICLR	MDGL
Revenue CAGR (5Y)	20.93%	N/A
EPS CAGR (5Y)	-14.23%	N/A
FCF CAGR (5Y)	22.10%	N/A
Total return CAGR (5Y)	-8.50%	44.41%

Frequently asked

Is ICLR or MDGL more profitable?: ICLR runs the higher net margin — ICLR at 3.99% versus MDGL at -25.32%.
How have ICLR and MDGL total returns compared?: Over the past 10 years, ICLR delivered 8.07% and MDGL delivered 41.50% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ICLR analysis Full MDGL analysis Interactive comparison tool

Dig into the metrics

ICON Public P/E ratio ICON Public ROE Madrigal Pharmaceuticals ROE ICON Public operating margin Madrigal Pharmaceuticals operating margin ICON Public revenue growth Madrigal Pharmaceuticals revenue growth ICON Public free cash flow Madrigal Pharmaceuticals free cash flow

ICON Public & Madrigal Pharmaceuticals appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.