How have IART and REPL total returns compared?

Over the past 5 years, IART delivered -28.16% and REPL delivered -15.17% annualized total return. Past performance doesn't predict future results.

Integra LifeSciences Holdings Corporation (IART) vs Replimune Group, Inc. (REPL)

A side-by-side comparison of Integra LifeSciences Holdings Corporation and Replimune Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

IART

Integra LifeSciences Holdings Corporation

$1.03B

$13.27HealthcareDelayed quote: Oct 6, 2026, 1:40 PM EDT

REPL

Replimune Group, Inc.

$1.10B

$13.07HealthcareDelayed quote: Oct 6, 2026, 1:40 PM EDT

Total return — IART vs REPL

growth of $100 · dividends reinvested · last 8y

IART -79.0% (-17.7%/yr)REPL -13.3% (-1.8%/yr)REPL compounded faster over this window

IART REPL

IART vs REPL: by the numbers

•REPL is the larger company ($1.10B vs $1.03B market cap).
•Both run net losses; REPL's is the smaller (0.00% vs -0.44% net margin).

Metrics side by side

Valuation

Metric	IART	REPL
Forward P/E	5.44	N/A
P/S ratio	0.63	N/A
P/B ratio	0.98	10.40
EV / EBITDA	3.53	N/A

Profitability

Metric	IART	REPL
Gross margin	53.74%	0.00%
Operating margin	4.18%	0.00%
Net margin	-0.44%	0.00%
ROE	-0.69%	-281.14%
ROIC	20.01%	-139.11%

Growth (annualized)

Metric	IART	REPL
Revenue CAGR (5Y)	1.77%	N/A
Total return CAGR (5Y)	-28.16%	-15.17%

Frequently asked

How have IART and REPL total returns compared?: Over the past 5 years, IART delivered -28.16% and REPL delivered -15.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full IART analysis Full REPL analysis Interactive comparison tool

Dig into the metrics

Integra LifeSciences ROE Replimune ROE Integra LifeSciences operating margin Replimune operating margin Integra LifeSciences revenue growth Replimune revenue growth Integra LifeSciences free cash flow Replimune free cash flow

Integra LifeSciences & Replimune appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.