Which has the lower trailing P/E, HSIC or KRYS?

HSIC has the lower trailing P/E: HSIC trades at 24.70 and KRYS at 40.86. P/E is one valuation measure and does not by itself establish which business is cheaper.

Is HSIC or KRYS more profitable?

KRYS runs the higher net margin — HSIC at 2.96% versus KRYS at 54.82%.

How have HSIC and KRYS total returns compared?

Over the past 5 years, HSIC delivered 1.39% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Henry Schein, Inc. (HSIC) vs Krystal Biotech, Inc. (KRYS)

A side-by-side comparison of Henry Schein, Inc. and Krystal Biotech, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

HSIC

Henry Schein, Inc.

$9.65B

$84.73HealthcareDelayed quote: Oct 6, 2026, 1:05 PM EDT

KRYS

Krystal Biotech, Inc.

$9.61B

$326.07HealthcareDelayed quote: Oct 6, 2026, 1:05 PM EDT

Total return — HSIC vs KRYS

growth of $100 · dividends reinvested · last 9y

HSIC +22.1% (+2.2%/yr)KRYS +3047.1% (+46.7%/yr)KRYS compounded faster over this window

Log scale — wide-divergence pair

HSIC KRYS

HSIC vs KRYS: by the numbers

•HSIC is the larger company ($9.65B vs $9.61B market cap).
•HSIC trades at the lower trailing earnings multiple (24.70 vs 40.86 P/E), one valuation lens rather than an overall verdict.
•KRYS converts more revenue to profit (54.82% vs 2.96% net margin).

Metrics side by side

Valuation

Metric	HSIC	KRYS
P/E ratio	24.70	40.86
Forward P/E	15.73	42.86
PEG ratio	7.82	N/A
P/S ratio	0.71	21.82
P/B ratio	3.06	7.07
EV / EBITDA	12.24	44.98
FCF yield	5.58%	2.68%

Profitability

Metric	HSIC	KRYS
Gross margin	30.31%	93.34%
Operating margin	5.69%	44.93%
Net margin	2.96%	54.82%
ROE	12.77%	17.77%
ROIC	6.53%	14.41%

Growth (annualized)

Metric	HSIC	KRYS
Revenue CAGR (5Y)	2.71%	N/A
EPS CAGR (5Y)	3.14%	N/A
FCF CAGR (5Y)	0.82%	N/A
Total return CAGR (5Y)	1.39%	44.28%

Frequently asked

Which has the lower trailing P/E, HSIC or KRYS?: HSIC has the lower trailing P/E: HSIC trades at 24.70 and KRYS at 40.86. P/E is one valuation measure and does not by itself establish which business is cheaper.
Is HSIC or KRYS more profitable?: KRYS runs the higher net margin — HSIC at 2.96% versus KRYS at 54.82%.
How have HSIC and KRYS total returns compared?: Over the past 5 years, HSIC delivered 1.39% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Go deeper

Full HSIC analysis Full KRYS analysis Interactive comparison tool

Dig into the metrics

Henry Schein P/E ratio Krystal Biotech P/E ratio Henry Schein ROE Krystal Biotech ROE Henry Schein operating margin Krystal Biotech operating margin Henry Schein revenue growth Krystal Biotech revenue growth Henry Schein free cash flow Krystal Biotech free cash flow

Henry Schein & Krystal Biotech appear in these rankings

Highest Operating Margin Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.