Harmony Biosciences Holdings, Inc. (HRMY) vs Supernus Pharmaceuticals, Inc. (SUPN)
A side-by-side comparison of Harmony Biosciences Holdings, Inc. and Supernus Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
HRMY
Harmony Biosciences Holdings, Inc.
$39.36HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
SUPN
Supernus Pharmaceuticals, Inc.
$42.83HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — HRMY vs SUPN
growth of $100 · dividends reinvested · last 6yHRMY +7.9% (+1.3%/yr)SUPN +70.7% (+9.3%/yr)SUPN compounded faster over this window
HRMY SUPN
HRMY vs SUPN: by the numbers
- •SUPN is the larger company ($2.49B vs $2.28B market cap).
- •HRMY is profitable (18.88% net margin) while SUPN runs a net loss (-13.23%).
- •HRMY grew revenue faster over the past five years (32.47% vs 7.78% CAGR).
Metrics side by side
Valuation
| Metric | HRMY | SUPN |
|---|---|---|
| P/E ratio | 12.78 | N/A |
| Forward P/E | 9.98 | 16.70 |
| P/S ratio | 2.37 | 2.99 |
| P/B ratio | 2.28 | 2.41 |
| EV / EBITDA | 7.36 | N/A |
| FCF yield | 15.57% | 0.76% |
Profitability
| Metric | HRMY | SUPN |
|---|---|---|
| Gross margin | 75.42% | 88.07% |
| Operating margin | 24.03% | -5.13% |
| Net margin | 18.88% | -13.23% |
| ROE | 18.14% | -10.66% |
| ROIC | 14.96% | -10.24% |
Growth (annualized)
| Metric | HRMY | SUPN |
|---|---|---|
| Revenue CAGR (5Y) | 32.47% | 7.78% |
| FCF CAGR (5Y) | 48.43% | -30.77% |
| Total return CAGR (5Y) | 0.91% | 9.85% |
Frequently asked
- Which has grown faster, HRMY or SUPN?
- Over the past five years, HRMY grew revenue faster — HRMY at a 32.47% CAGR versus SUPN at 7.78%.
- Is HRMY or SUPN more profitable?
- HRMY runs the higher net margin — HRMY at 18.88% versus SUPN at -13.23%.
- How have HRMY and SUPN total returns compared?
- Over the past 5 years, HRMY delivered 0.91% and SUPN delivered 9.85% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Harmony Biosciences P/E ratioHarmony Biosciences ROESupernus Pharmaceuticals ROEHarmony Biosciences operating marginSupernus Pharmaceuticals operating marginHarmony Biosciences revenue growthSupernus Pharmaceuticals revenue growthHarmony Biosciences free cash flowSupernus Pharmaceuticals free cash flow
Harmony Biosciences & Supernus Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.