Which has the lower trailing P/E, HRMY or INSP?

HRMY has the lower trailing P/E: HRMY trades at 12.97 and INSP at 15.02. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, HRMY or INSP?

Over the past five years, INSP grew revenue faster — HRMY at a 32.47% CAGR versus INSP at 38.69%.

Is HRMY or INSP more profitable?

HRMY runs the higher net margin — HRMY at 18.88% versus INSP at 15.03%.

How have HRMY and INSP total returns compared?

Over the past 5 years, HRMY delivered 0.91% and INSP delivered -21.38% annualized total return. Past performance doesn't predict future results.

Harmony Biosciences Holdings, Inc. (HRMY) vs Inspire Medical Systems, Inc. (INSP)

A side-by-side comparison of Harmony Biosciences Holdings, Inc. and Inspire Medical Systems, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

HRMY

Harmony Biosciences Holdings, Inc.

$2.31B

$39.94HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT

INSP

Inspire Medical Systems, Inc.

$2.01B

$69.40HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT

Total return — HRMY vs INSP

growth of $100 · dividends reinvested · last 6y

HRMY +7.9% (+1.3%/yr)INSP -34.1% (-6.7%/yr)HRMY compounded faster over this window

HRMY INSP

HRMY vs INSP: by the numbers

•HRMY is the larger company ($2.31B vs $2.01B market cap).
•HRMY trades at the lower trailing earnings multiple (12.97 vs 15.02 P/E), one valuation lens rather than an overall verdict.
•HRMY converts more revenue to profit (18.88% vs 15.03% net margin).
•INSP grew revenue faster over the past five years (38.69% vs 32.47% CAGR).

Metrics side by side

Valuation

Metric	HRMY	INSP
P/E ratio	12.97	15.02
Forward P/E	10.13	58.11
P/S ratio	2.41	2.23
P/B ratio	2.31	2.43
EV / EBITDA	7.49	26.75
FCF yield	15.35%	5.84%

Profitability

Metric	HRMY	INSP
Gross margin	75.42%	86.13%
Operating margin	24.03%	6.02%
Net margin	18.88%	15.03%
ROE	18.14%	16.36%
ROIC	14.96%	6.33%

Growth (annualized)

Metric	HRMY	INSP
Revenue CAGR (5Y)	32.47%	38.69%
FCF CAGR (5Y)	48.43%	N/A
Total return CAGR (5Y)	0.91%	-21.38%

Frequently asked

Which has the lower trailing P/E, HRMY or INSP?: HRMY has the lower trailing P/E: HRMY trades at 12.97 and INSP at 15.02. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, HRMY or INSP?: Over the past five years, INSP grew revenue faster — HRMY at a 32.47% CAGR versus INSP at 38.69%.
Is HRMY or INSP more profitable?: HRMY runs the higher net margin — HRMY at 18.88% versus INSP at 15.03%.
How have HRMY and INSP total returns compared?: Over the past 5 years, HRMY delivered 0.91% and INSP delivered -21.38% annualized total return. Past performance doesn't predict future results.

Go deeper

Full HRMY analysis Full INSP analysis Interactive comparison tool

Dig into the metrics

Harmony Biosciences P/E ratio Inspire Medical Systems P/E ratio Harmony Biosciences ROE Inspire Medical Systems ROE Harmony Biosciences operating margin Inspire Medical Systems operating margin Harmony Biosciences revenue growth Inspire Medical Systems revenue growth Harmony Biosciences free cash flow Inspire Medical Systems free cash flow

Harmony Biosciences & Inspire Medical Systems appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.