Is HELP or WVE more profitable?

HELP runs the higher net margin — HELP at 329.09% versus WVE at -309.73%.

Helus Pharma Inc. (HELP) vs Wave Life Sciences Ltd. (WVE)

A side-by-side comparison of Helus Pharma Inc. and Wave Life Sciences Ltd. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

HELP

Helus Pharma Inc.

$667M

$10.76HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

WVE

Wave Life Sciences Ltd.

$694M

$3.52HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — HELP vs WVE

growth of $100 · dividends reinvested · last 1y

HELP +93.2% (+93.2%/yr)WVE -79.8% (-79.8%/yr)HELP compounded faster over this window

Log scale — wide-divergence pair

HELP WVE

HELP vs WVE: by the numbers

•WVE is the larger company ($694M vs $667M market cap).
•HELP is profitable (329.09% net margin) while WVE runs a net loss (-309.73%).

Metrics side by side

Valuation

Metric	HELP	WVE
P/S ratio	N/A	10.61
P/B ratio	2.76	1.53

Profitability

Metric	HELP	WVE
Gross margin	100.27%	79.28%
Operating margin	317.06%	-504.09%
Net margin	329.09%	-309.73%
ROE	-75.79%	-44.64%
ROIC	-73.27%	-42.94%

Growth (annualized)

Metric	HELP	WVE
Revenue CAGR (5Y)	N/A	33.08%
Total return CAGR (5Y)	N/A	-4.33%

Frequently asked

Is HELP or WVE more profitable?: HELP runs the higher net margin — HELP at 329.09% versus WVE at -309.73%.

Go deeper

Full HELP analysis Full WVE analysis Interactive comparison tool

Dig into the metrics

Helus Pharma ROE Wave Life Sciences ROE Helus Pharma operating margin Wave Life Sciences operating margin Helus Pharma revenue growth Wave Life Sciences revenue growth Helus Pharma free cash flow Wave Life Sciences free cash flow

Helus Pharma & Wave Life Sciences appear in these rankings

Fastest Revenue Growth Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.