Which has the lower trailing P/E, HALO or PEN?

HALO has the lower trailing P/E: HALO trades at 32.75 and PEN at 77.99. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, HALO or PEN?

Over the past five years, HALO grew revenue faster — HALO at a 32.18% CAGR versus PEN at 17.52%.

Is HALO or PEN more profitable?

HALO runs the higher net margin — HALO at 24.86% versus PEN at 10.67%.

How have HALO and PEN total returns compared?

Over the past 10 years, HALO delivered 24.30% and PEN delivered 15.63% annualized total return. Past performance doesn't predict future results.

Halozyme Therapeutics, Inc. (HALO) vs Penumbra, Inc. (PEN)

A side-by-side comparison of Halozyme Therapeutics, Inc. and Penumbra, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

HALO

Halozyme Therapeutics, Inc.

$13.01B

$109.70HealthcareDelayed quote: Oct 6, 2026, 9:40 AM EDT

PEN

Penumbra, Inc.

$12.50B

$317.41HealthcareDelayed quote: Oct 6, 2026, 9:40 AM EDT

Total return — HALO vs PEN

growth of $100 · dividends reinvested · last 10y

HALO +779.9% (+24.3%/yr)PEN +327.2% (+15.6%/yr)HALO compounded faster over this window

HALO PEN

HALO vs PEN: by the numbers

•HALO is the larger company ($13.01B vs $12.50B market cap).
•HALO trades at the lower trailing earnings multiple (32.75 vs 77.99 P/E), one valuation lens rather than an overall verdict.
•HALO converts more revenue to profit (24.86% vs 10.67% net margin).
•HALO grew revenue faster over the past five years (32.18% vs 17.52% CAGR).

Metrics side by side

Valuation

Metric	HALO	PEN
P/E ratio	32.75	77.99
Forward P/E	13.04	67.42
PEG ratio	1.43	N/A
P/S ratio	7.82	8.31
P/B ratio	90.65	8.17
EV / EBITDA	14.22	61.18
FCF yield	6.20%	1.73%

Profitability

Metric	HALO	PEN
Gross margin	78.18%	67.84%
Operating margin	56.77%	12.45%
Net margin	24.86%	10.67%
ROE	288.13%	10.49%
ROIC	27.42%	8.48%

Growth (annualized)

Metric	HALO	PEN
Revenue CAGR (5Y)	32.18%	17.52%
EPS CAGR (5Y)	22.68%	N/A
FCF CAGR (5Y)	40.08%	N/A
Total return CAGR (5Y)	22.18%	4.16%

Frequently asked

Which has the lower trailing P/E, HALO or PEN?: HALO has the lower trailing P/E: HALO trades at 32.75 and PEN at 77.99. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, HALO or PEN?: Over the past five years, HALO grew revenue faster — HALO at a 32.18% CAGR versus PEN at 17.52%.
Is HALO or PEN more profitable?: HALO runs the higher net margin — HALO at 24.86% versus PEN at 10.67%.
How have HALO and PEN total returns compared?: Over the past 10 years, HALO delivered 24.30% and PEN delivered 15.63% annualized total return. Past performance doesn't predict future results.

Go deeper

Full HALO analysis Full PEN analysis Interactive comparison tool

Dig into the metrics

Halozyme Therapeutics P/E ratio Penumbra P/E ratio Halozyme Therapeutics ROE Penumbra ROE Halozyme Therapeutics operating margin Penumbra operating margin Halozyme Therapeutics revenue growth Penumbra revenue growth Halozyme Therapeutics free cash flow Penumbra free cash flow

Halozyme Therapeutics & Penumbra appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.